APOE Monoclonal Antibody (GT1627)

beta-amyloid binding receptor binding structural molecule activity lipid transporter activity protein binding phospholipid binding heparin binding lipid binding antioxidant activity enzyme binding identical protein binding protein homodimerization activity heparan sulfate proteoglycan binding macromolecular complex binding metal chelating activity protein dimerization activity receptor agonist activity tau protein binding low-density lipoprotein particle receptor binding phosphatidylcholine-sterol O-acyltransferase activator activity very-low-density lipoprotein particle receptor binding lipoprotein particle binding intermembrane cholesterol transfer activity hydroxyapatite binding

response to reactive oxygen species retinoid metabolic process negative regulation of endothelial cell proliferation triglyceride metabolic process lipid transport receptor-mediated endocytosis cytoskeleton organization G-protein coupled receptor signaling pathway synaptic transmission, cholinergic long-term memory cholesterol metabolic process negative regulation of platelet activation negative regulation of endothelial cell migration negative regulation of gene expression negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of cholesterol efflux lipid transport involved in lipid storage positive regulation of neuron projection development negative regulation of neuron projection development long-chain fatty acid transport protein import virion assembly negative regulation of blood coagulation regulation of axon extension neuron projection development melanosome organization regulation of Cdc42 protein signal transduction positive regulation of low-density lipoprotein particle receptor catabolic process cholesterol efflux phospholipid efflux very-low-density lipoprotein particle remodeling low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly chylomicron remnant clearance high-density lipoprotein particle clearance very-low-density lipoprotein particle clearance locomotory exploration behavior nitric oxide-cGMP-mediated signaling pathway lipoprotein metabolic process lipoprotein biosynthetic process cholesterol homeostasis regulation of apoptotic process amyloid precursor protein metabolic process regulation of protein complex assembly negative regulation of MAPK cascade negative regulation of blood vessel endothelial cell migration reverse cholesterol transport positive regulation by host of viral process regulation of innate immune response positive regulation of nitric oxide biosynthetic process negative regulation of cholesterol biosynthetic process positive regulation of endocytosis positive regulation of transcription, DNA-templated positive regulation of lipid biosynthetic process regulation of neuronal synaptic plasticity negative regulation of smooth muscle cell proliferation negative regulation of protein secretion negative regulation of inflammatory response regulation of synapse organization positive regulation of membrane protein ectodomain proteolysis negative regulation of lipid biosynthetic process regulation of protein metabolic process negative regulation of protein metabolic process fatty acid homeostasis acylglycerol homeostasis positive regulation of dendritic spine development negative regulation of dendritic spine development regulation of proteasomal protein catabolic process response to caloric restriction triglyceride homeostasis positive regulation of ERK1 and ERK2 cascade cellular response to lipoprotein particle stimulus triglyceride-rich lipoprotein particle clearance intermediate-density lipoprotein particle clearance negative regulation of canonical Wnt signaling pathway regulation of cholesterol metabolic process positive regulation of cholesterol metabolic process negative regulation of cholesterol efflux regulation of plasma lipoprotein particle levels AMPA glutamate receptor clustering NMDA glutamate receptor clustering cellular oxidant detoxification positive regulation of lipoprotein transport regulation of beta-amyloid clearance positive regulation of beta-amyloid clearance negative regulation of long-term synaptic potentiation negative regulation of postsynaptic membrane organization positive regulation of presynaptic membrane organization positive regulation of beta-amyloid formation negative regulation of beta-amyloid formation negative regulation of dendritic spine maintenance positive regulation of dendritic spine maintenance regulation of amyloid precursor protein catabolic process positive regulation of phospholipid efflux positive regulation of neurofibrillary tangle assembly negative regulation of phospholipid efflux negative regulation of lipid transport across blood brain barrier positive regulation of lipid transport across blood brain barrier regulation of cellular response to very-low-density lipoprotein particle stimulus regulation of amyloid fibril formation negative regulation of amyloid fibril formation positive regulation of amyloid fibril formation regulation of behavioral fear response blood vessel development response to dietary excess lipid metabolic process fatty acid metabolic process cholesterol catabolic process cellular calcium ion homeostasis response to oxidative stress signal transduction response to zinc ion gene expression regulation of gene expression peripheral nervous system axon regeneration neuron projection regeneration response to retinoic acid response to insulin response to tumor necrosis factor lipoprotein catabolic process vasodilation response to ethanol positive regulation of axon extension negative regulation of lipid metabolic process oligodendrocyte differentiation artery morphogenesis maintenance of location in cell calcium ion homeostasis lipid homeostasis artery development cellular response to interleukin-1 cellular response to ethanol cellular response to growth factor stimulus cellular response to cholesterol circulatory system development regulation of triglyceride metabolic process negative regulation of triglyceride metabolic process response to D-galactosamine