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Invitrogen

Phospho-CDK2 (Tyr15) Recombinant Rabbit Monoclonal Antibody (HL1474)

View all (70) CDK2 antibodies

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Product Details

MA5-50316

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Fruit fly, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1474

Immunogen

Carrier-protein conjugated synthetic peptide corresponding to residues around human CDK2 (phospho Tyr15). The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094391

Target Information

CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; cdc2c; CDK1; CDK2; Cdk2-PA; Cdk2-PB; Cdk2-PC; cell division protein kinase 2; CG10498-PA; CG10498-PB; CG10498-PC; cyclin dependent kinase 2-alpha; cyclin E; cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; LD22351p; MPF; p33 protein kinase; p33CDK2; p34 protein kinase; unnamed protein product

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Gene Aliases: A630093N05Rik; CDC2C; CDK2; CDK2/CDC2c; CDKN2; CG10498; Dcdc2c; dCdk2; DmCdc2c; DmCdk2; Dmel\CG10498; Dmel_CG10498; p33(CDK2); S(Sev-CycE)3A

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UniProt ID: (Human) P24941, (Fruit fly) P23573, (Mouse) P97377

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Entrez Gene ID: (Human) 1017, (Rat) 362817, (Fruit fly) 42453, (Mouse) 12566

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding kinase activity protein domain specific binding cyclin binding histone kinase activity cyclin-dependent protein kinase activity protein serine kinase activity macromolecular complex binding non-receptor serine/threonine protein kinase
Process(es)
G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle DNA replication chromatin remodeling protein phosphorylation centriole replication signal transduction Ras protein signal transduction regulation of mitotic cell cycle positive regulation of cell proliferation peptidyl-serine phosphorylation positive regulation of heterochromatin assembly mitotic G1 DNA damage checkpoint telomere maintenance in response to DNA damage post-translational protein modification positive regulation of DNA replication centrosome duplication meiotic cell cycle cellular response to nitric oxide cellular senescence negative regulation of protein localization to chromatin regulation of heterochromatin organization regulation of anaphase-promoting complex-dependent catabolic process negative regulation of transcription from RNA polymerase II promoter lens development in camera-type eye potassium ion transport cellular response to DNA damage stimulus response to xenobiotic stimulus response to toxic substance positive regulation of DNA-dependent DNA replication initiation response to estradiol cellular response to insulin stimulus negative regulation of protein catabolic process response to ethanol positive regulation of transcription, DNA-templated response to cadmium ion response to cAMP response to electrical stimulus liver regeneration positive regulation of meiotic cell cycle process involved in oocyte maturation DNA synthesis involved in mitotic DNA replication regulation of G2/M transition of mitotic cell cycle regulation of gene expression positive regulation of JAK-STAT cascade telomere maintenance protection from non-homologous end joining at telomere regulation of cell cycle
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