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Invitrogen
GLT-1 Recombinant Rabbit Monoclonal Antibody (PS01-62)
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FIGURE: 1 / 4
GLT-1 Antibody (MA5-50813) in IHC (P)
Immunohistochemistry of GLT-1 in paraffin-embedded mouse cerebellum tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with GLT-1 recombinant monoclonal antibody (Product # MA5-50813) with a dilution of 1:1,000 for 1 hour at r... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-50813
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PS01-62
Immunogen
Synthetic peptide within Human GLT-1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive control: Mouse brain tissue lysate, rat brain tissue lysate, mouse cerebellum tissue lysate, mouse brain tissue, mouse cerebellum tissue, rat cerebellum tissue.
Predicted band size: 62 kDa
Subcellular Location: Cell membrane.
Target Information
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; EAAT2; EAAT2 variant mEAAT2/5UT2; EAAT2 variant mEAAT2/5UT5; excitotoxic amino acid transporter 2; glial glutamate transporter GLT1/V1; glial glutamate transporter GLT1/V2; glial glutamate transporter GLT1/V3; glial glutamate transporter GLT1/V4; GLT1 variant; transmembrane glycoprotein; GLT1a; GLT1b; GLT1c; glutamate transporter 1; glutamate transporter 1c; glutamate transporter-1; glutamate/aspartate transporter II; high affinity glucose transporter; human brain glutamate transporter; mGLT-1; mGLT-1A; mGLT-1B; OTTHUMP00000165209; OTTHUMP00000165210; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1, member 2; unnamed protein product
Gene Aliases: 1700091C19Rik; 2900019G14Rik; DEE41; EAAT2; EIEE41; Glt; GLT-1; GLT1; HBGT; MGLT1
UniProt ID: (Human) P43004, (Mouse) P43006, (Rat) P31596
Entrez Gene ID: (Human) 6506, (Mouse) 20511, (Rat) 29482
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
anion transmembrane transporter activity
neutral amino acid transmembrane transporter activity
symporter activity
glutamate:sodium symporter activity
cysteine transmembrane transporter activity
glutathione biosynthetic process
nervous system development
visual behavior
response to xenobiotic stimulus
response to light stimulus
response to wounding
neutral amino acid transport
L-glutamate transport
telencephalon development
adult behavior
multicellular organism growth
response to amino acid
positive regulation of glucose import
protein homotrimerization
L-aspartate transmembrane transport
D-aspartate import
cellular response to cocaine
cellular response to hypoxia
anion transmembrane transport
L-glutamate import across plasma membrane
neurotransmitter reuptake
L-aspartate import across plasma membrane
cysteine transmembrane transport
neurotransmitter transport
response to ethanol
response to antibiotic
amino acid transport
chemical synaptic transmission
transepithelial transport
glutamate homeostasis
import into cell
transport across blood-brain barrier
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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