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          • Primary Antibodies ›
          • ERK2 Antibodies

          Invitrogen

          ERK2 Monoclonal Antibody (C1)

          View all (72) ERK2 antibodies

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          Cite ERK2 Monoclonal Antibody (C1)

          Additional Information:
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          • Antibody Testing Data (6)
          ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 6

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          ERK2 Antibody (MA5-50855) in IHC (P)

          Immunohistochemistry (Paraffin) analysis of ERK2 in Human Thyroid cancer Tissue. Samples were incubated in ERK2 monoclonal antibody (Product # MA5-50855) using a dilution of 20 μg/mL followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          ERK2 Antibody in Western Blot (WB)
          ERK2 Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          ERK2 Monoclonal Antibody (C1)

          Product Details

          MA5-50855

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.01-2 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          5-20 µg/mL
          -
          Product Specifications

          Species Reactivity

          Bovine, Dog, Chicken, Guinea pig, Goat, Human, Mouse, Sheep, Pig, Rat

          Host/Isotype

          Mouse / IgG2a, kappa

          Class

          Monoclonal

          Type

          Antibody

          Clone

          C1

          Immunogen

          Recombinant Human ERK2 protein, Tyr25-Ser360 (Accession #P28482)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          200 µg

          Purification

          Protein A/G

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.05% Proclin 300

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3094359

          Target Information

          MAPK1 (ERK2) is a serine/threonine kinase that acts as an important activator of p90 RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ERK-2; Erk2; cancer susceptibility protein; ERT1; extracellular regulated protein 2; extracellular signal-regulated kinase 2; extracellular signal-regulated kinase-2; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; mitogen-activated protein kinase; mitogen-activated protein kinase 2; p42-MAPK; protein tyrosine kinase ERK2; unnamed protein product

          View more View less

          Gene Aliases: 9030612K14Rik; ERK; ERK-2; ERK2; ERT1; MAPK1; MAPK2; NS13; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2

          View more View less

          UniProt ID: (Bovine) P46196, (Human) P28482, (Rat) P63086, (Mouse) P63085

          View more View less

          Entrez Gene ID: (Bovine) 327672, (Pig) 100153927, (Goat) 102186040, (Human) 5594, (Dog) 477575, (Sheep) 101115485, (Chicken) 373953, (Guinea pig) 100715180, (Rat) 116590, (Mouse) 26413

          View more View less

          Function(s)
          phosphotyrosine binding protein serine/threonine kinase activity MAP kinase kinase activity ATP binding RNA polymerase II carboxy-terminal domain kinase activity phosphatase binding identical protein binding protein kinase activity MAP kinase activity protein binding kinase activity protein serine kinase activity double-stranded DNA binding protein kinase binding mitogen-activated protein kinase kinase kinase binding non-receptor serine/threonine protein kinase
          Process(es)
          activation of MAPK activity protein phosphorylation apoptotic process cellular response to DNA damage stimulus cell cycle positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cytosine metabolic process regulation of ossification regulation of cellular pH thyroid gland development regulation of protein stability lipopolysaccharide-mediated signaling pathway positive regulation of telomere maintenance via telomerase mammary gland epithelial cell proliferation cellular response to amino acid starvation cellular response to reactive oxygen species response to nicotine ERBB signaling pathway outer ear morphogenesis response to exogenous dsRNA negative regulation of cell differentiation thymus development T cell receptor signaling pathway B cell receptor signaling pathway stress-activated MAPK cascade positive regulation of telomerase activity Bergmann glial cell differentiation long-term synaptic potentiation face development lung morphogenesis trachea formation labyrinthine layer blood vessel development cardiac neural crest cell development involved in heart development ERK1 and ERK2 cascade response to epidermal growth factor cellular response to cadmium ion cellular response to tumor necrosis factor cellular response to granulocyte macrophage colony-stimulating factor stimulus cellular response to dopamine positive regulation of telomere capping MAPK cascade regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway chemical synaptic transmission learning or memory insulin receptor signaling pathway positive regulation of macrophage chemotaxis Schwann cell development positive regulation of telomere maintenance regulation of stress-activated MAPK cascade intracellular signal transduction ERBB2-ERBB3 signaling pathway myelination positive regulation of skeletal muscle tissue regeneration positive regulation of cholesterol biosynthetic process positive regulation of smoothened signaling pathway insulin-like growth factor receptor signaling pathway regulation of cytoskeleton organization interleukin-34-mediated signaling pathway chemokine-mediated signaling pathway caveolin-mediated endocytosis regulation of Golgi inheritance positive regulation of macrophage proliferation positive regulation of neuroinflammatory response regulation of early endosome to late endosome transport heart development positive regulation of cell proliferation response to toxic substance organ morphogenesis neural crest cell development diadenosine tetraphosphate biosynthetic process sensory perception of pain positive regulation of cell migration response to estradiol response to lipopolysaccharide response to testosterone cellular response to platelet-derived growth factor stimulus response to cocaine positive regulation of protein import into nucleus response to hydrogen peroxide response to estrogen estrous cycle positive regulation of translation positive regulation of transcription, DNA-templated decidualization regulation of intracellular pH positive regulation of cardiac muscle cell proliferation cellular response to methionine cellular response to cAMP cellular response to epidermal growth factor stimulus cellular response to peptide hormone stimulus cellular response to prostaglandin E stimulus cellular response to lipid cellular response to toxic substance response to alcohol cellular response to insulin-like growth factor stimulus placenta development
          It has to be done as per old AB suggested Products section.

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