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Invitrogen

Progesterone Receptor Recombinant Rabbit Monoclonal Antibody (3S3D1)

View all (151) Progesterone Receptor antibodies

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Product Details

MA5-51347

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3S3D1

Immunogen

Recombinant protein of human Progesterone Receptor.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094303

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: nuclear receptor subfamily 3 group C member 3; PR; unnamed protein product

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Gene Aliases: 9930019P03Rik; NR3C3; PR; PR-A; PR-B

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UniProt ID: (Human) P06401, (Mouse) Q00175, (Rat) Q63449

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Entrez Gene ID: (Human) 5241, (Mouse) 18667, (Rat) 25154

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding steroid binding protein binding zinc ion binding enzyme binding estrogen response element binding identical protein binding sequence-specific DNA binding ATPase binding sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding hormone binding
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter signal transduction cell-cell signaling positive regulation of gene expression negative regulation of gene expression intracellular steroid hormone receptor signaling pathway negative regulation of phosphorylation steroid hormone mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter progesterone receptor signaling pathway maintenance of protein location in nucleus ovulation from ovarian follicle epithelial cell maturation positive regulation of cell proliferation female gonad development positive regulation of smooth muscle cell migration ovulation cycle process mammary gland development paracrine signaling response to cocaine negative regulation of apoptotic process positive regulation of transcription, DNA-templated lung alveolus development regulation of epithelial cell proliferation female mating behavior tertiary branching involved in mammary gland duct morphogenesis negative regulation of granulosa cell apoptotic process luteinization diterpenoid metabolic process response to progesterone response to estrogen estrous cycle negative regulation of transcription, DNA-templated smooth muscle relaxation of the bladder outlet cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to estrogen stimulus response to ketone cellular response to wortmannin
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