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Invitrogen
UGT1A1 Recombinant Rabbit Monoclonal Antibody (4R6Q0)
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FIGURE: 1 / 2
UGT1A1 Antibody (MA5-51463) in ICC/IF
Immunocytochemistry (confocal imaging) analysis of UGT1A1 in NIH/3T3 cells. Samples were incubated with UGT1A1 Recombinant monoclonal antibody (Product # MA5-51463) using a dilution of 1:200 (Red). The cells were counterstained with alpha-Tubulin Mouse mAb (Product # MA5-38221, dilution 1:400) (Green). DAPI was used for nuclear staining (Blue). Objective: 60x.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-51463
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4R6Q0
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.34 mg/mL
Amount
34 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FENDSFLQRV IKTYKKIKKD SAMLLSGCSH LLHNKELMAS LAESSFDVML TDPFLPCSPI VAQYLSLPTV FFLHALPCSL EFEATQCPNP FSYVPRPLSS H
Target Information
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B1; EC 2.4.1.17; HUG BR1; HUGBR1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1-1; UDPGT; UGT 1A; UGT1 01; UGT1*1; UGT1-01; UGT1.1; UGT1A1
Gene Aliases: Gnt1; Udpgt; UDPGT 1-1; Udpgt-1a; Ugt1; UGT1A01; UgtBr1
UniProt ID: (Mouse) Q63886, (Rat) Q64550
Entrez Gene ID: (Mouse) 394436, (Rat) 24861
cell activation
liver development
protein phosphorylation
bilirubin conjugation
xenobiotic metabolic process
inflammatory response
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
estrogen metabolic process
response to toxic substance
flavonoid metabolic process
gene expression
sterol metabolic process
hepatic stellate cell activation
heme catabolic process
pigment accumulation
response to arsenic-containing substance
digestive tract development
protein homooligomerization
protein heterooligomerization
flavone metabolic process
biphenyl catabolic process
cellular response to glucocorticoid stimulus
connective tissue replacement
acute-phase response
response to nutrient
response to xenobiotic stimulus
organ regeneration
response to lipopolysaccharide
cellular response to hormone stimulus
response to starvation
response to ethanol
response to steroid hormone
response to glucocorticoid
cellular response to ethanol
cellular response to estradiol stimulus
cellular response to xenobiotic stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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