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Invitrogen

Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant Rabbit Monoclonal Antibody (8H4J9)

View all (2) HDAC4/HDAC5/HDAC9 antibodies

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Product Details

MA5-51562

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8H4J9

Immunogen

Synthetic peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.84 mg/mL

Amount

84 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094411

Target Information

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen NY-CO-9; class II histone deacetylase; DKFZp779K1053; HD4; hdac-9; HDAC4; HDAC5; HDRP; HDRPa; histone deacetylase 4; histone deacetylase 4/5-related protein; histone deacetylase 7B; histone deacetylase A; histone deacetylase mHDA1; histone deacetylase-related protein; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; MEF2-interacting transcriptional repressor; protein deacetylase; putative Type II integral membrane protein; unnamed protein product

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Gene Aliases: 4932408F19Rik; AHO3; BDMR; D030072B18Rik; HA6116; HD4; HD5; HD7; HD7B; HD9; HDAC; HDAC-4; HDAC-A; Hdac4; HDAC7B; HDAC9B; HDAC9FL; HDACA; HDRP; mHDA1; MITR; mKIAA0600; mKIAA0744; NEDCHF; NEDCHID; NY-CO-9; RGD1310748; RGD1563092

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UniProt ID: (Human) P56524, (Human) Q9UQL6, (Human) Q9UKV0, (Rat) Q99P99, (Mouse) Q6NZM9, (Mouse) Q99N13

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Entrez Gene ID: (Human) 9759, (Human) 10014, (Human) 9734, (Rat) 363287, (Mouse) 208727, (Mouse) 15184, (Rat) 84580, (Rat) 687001, (Mouse) 79221

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding SUMO transferase activity potassium ion binding protein deacetylase activity histone binding identical protein binding histone deacetylase binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism transcription corepressor binding chromatin binding protein kinase C binding transcription corepressor activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) DNA binding protein kinase binding promoter-specific chromatin binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin remodeling inflammatory response nervous system development positive regulation of cell proliferation negative regulation of myotube differentiation response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress protein sumoylation B cell differentiation positive regulation of protein sumoylation regulation of gene expression, epigenetic B cell activation negative regulation of gene expression, epigenetic negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway negative regulation of protein refolding response to interleukin-1 skeletal system development osteoblast development negative regulation of cell proliferation response to xenobiotic stimulus positive regulation of lamellipodium assembly regulation of cardiac muscle contraction by calcium ion signaling positive regulation of smooth muscle cell migration positive regulation of neuron apoptotic process negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development regulation of striated muscle cell differentiation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus response to alcohol positive regulation of male mating behavior negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process negative regulation of cytokine production response to amphetamine DNA repair heart development determination of adult lifespan neuron differentiation cellular response to insulin stimulus cholesterol homeostasis positive regulation of cell migration involved in sprouting angiogenesis chromatin organization negative regulation of gene expression regulation of myotube differentiation multicellular organismal response to stress response to cocaine negative regulation of striated muscle tissue development renal tubule morphogenesis cellular response to fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation response to activity cellular response to lipopolysaccharide
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