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Invitrogen

PAR2 Recombinant Rabbit Monoclonal Antibody (23GB5850)

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PAR2 Recombinant Rabbit Monoclonal Antibody (23GB5850)

Product Details

MA5-52930

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB5850

Immunogen

A synthesized peptide derived from human PAR2 (330-397AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3249405

Target Information

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; G-protein coupled receptor 11; G-protein-coulped receptor; PAR-2; protease-activated receptor 2; Protease-activated receptor-2; Proteinase-activated receptor-2, G protein-coupled receptor 11; thrombin receptor-like 1; unnamed protein product

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Gene Aliases: Gpcr11; GPR11; PAR-2; PAR2

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UniProt ID: (Human) P55085, (Rat) Q63645, (Mouse) P55086

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Entrez Gene ID: (Human) 2150, (Rat) 116677, (Mouse) 14063

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Function(s)
proteinase activated receptor activity G-protein alpha-subunit binding protease binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding signaling receptor activity heterotrimeric G-protein binding
Process(es)
T cell activation involved in immune response positive regulation of leukocyte chemotaxis positive regulation of cytokine production involved in immune response regulation of glomerular filtration positive regulation of glomerular filtration G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration blood coagulation negative regulation of tumor necrosis factor-mediated signaling pathway antimicrobial humoral response regulation of blood coagulation positive regulation of cell migration positive regulation of actin filament depolymerization positive regulation of pseudopodium assembly negative regulation of chemokine production positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of superoxide anion generation positive regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of Rho protein signal transduction neutrophil activation vasodilation regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of eosinophil degranulation cell-cell junction maintenance positive regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter regulation of JNK cascade negative regulation of JNK cascade positive regulation of JNK cascade leukocyte migration positive regulation of chemotaxis positive regulation of positive chemotaxis defense response to virus positive regulation of protein kinase B signaling positive regulation of phagocytosis, engulfment establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway leukocyte proliferation mature conventional dendritic cell differentiation positive regulation of renin secretion into blood stream regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of GTPase activity positive regulation of neutrophil mediated killing of gram-negative bacterium
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