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Invitrogen

NFkB p50/p105 Recombinant Rabbit Monoclonal Antibody (23GB2710)

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NFkB p50/p105 Recombinant Rabbit Monoclonal Antibody (23GB2710)

Product Details

MA5-53584

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB2710

Immunogen

A synthesized peptide derived from human NF-kB (p105/p50) (324-372AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.75 mg/mL

Amount

75 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3248055

Target Information

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686C01211; DNA-binding factor KBF1; EBP-1; MGC54151; NF kappaB1; NF KB; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB p50; NF-kB p50/p105; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; nuclear factor NF-kappa-B p50; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; p105; p50 subunit of NF kappaB; p50/p105; transcription factor p105 NF-kappa B precursor; unnamed protein product

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Gene Aliases: CVID12; EBP-1; KBF1; NF-kappa-B1; NF-kappaB; NF-kappaB1; NF-kappabeta; NF-kB; NF-KB1; NFkappaB; NFKB-p105; NFKB-p50; p105; p50; p50/p105

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UniProt ID: (Human) P19838, (Mouse) P25799, (Rat) Q63369

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Entrez Gene ID: (Human) 4790, (Mouse) 18033, (Rat) 81736

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity protein binding identical protein binding actinin binding sequence-specific DNA binding protein sequestering activity double-stranded DNA binding heat shock protein binding macromolecular complex binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade negative regulation of cytokine production regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling JNK cascade gene expression regulation of gene expression negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux positive regulation of lipid storage negative regulation of vitamin D biosynthetic process tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling negative regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response B cell receptor signaling pathway mammary gland involution positive regulation of transcription initiation from RNA polymerase II promoter cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to nicotine cellular response to interleukin-6 cellular response to tumor necrosis factor positive regulation of canonical Wnt signaling pathway cellular response to interleukin-17 cellular response to virus antibacterial innate immune response negative regulation of cytokine production involved in inflammatory response positive regulation of hyaluronan biosynthetic process cellular response to angiotensin positive regulation of miRNA metabolic process response to oxidative stress positive regulation of gene expression signal transduction involved in regulation of gene expression negative regulation of interleukin-12 production response to muscle stretch negative regulation of transcription, DNA-templated lymph node development positive regulation of inflammatory response cellular response to carbohydrate stimulus cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to dsRNA cellular response to peptide cellular response to diterpene cellular response to glucoside cellular response to brain-derived neurotrophic factor stimulus response to xenobiotic stimulus response to bacterium response to ethanol response to copper ion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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