Search

  • Contáctenos
  • Orden Rápida

Invitrogen

ZFP36 Monoclonal Antibody (K94030_9A2)

View all (11) ZFP36 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation'] || 'Additional Information'}}: {{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

{{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}
ZFP36 Monoclonal Antibody (K94030_9A2)

Product Details

MA5-55704

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunoprecipitation (IP)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

K94030_9A2

Immunogen

Recombinant human ZFP36 (immunogen range is 171-310).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.96 mg/mL

Amount

98 µg

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_3667936

Product Specific Information

Sequence of this protein is as follows: DLAAPGHPPV LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE AGVFAPPQPV

Target Information

ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: G0/G1 switch regulatory protein 24; growth factor-inducible nuclear protein NUP475; tristetraprolin; tristetraproline; unnamed protein product; ZFP36 ring finger protein; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog

View more View less

Gene Aliases: G0S24; GOS24; NUP475; RNF162A; TIS11; TTP; zfp-36

View more View less

UniProt ID: (Human) P26651

View more View less

Entrez Gene ID: (Human) 7538

View more View less

Function(s)
translation repressor activity, nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding enzyme binding protein kinase binding C-C chemokine binding heat shock protein binding mRNA 3'-UTR AU-rich region binding macromolecular complex binding metal ion binding RNA polymerase binding 14-3-3 protein binding protein-RNA sequence-specific adaptor activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening mRNA catabolic process response to wounding regulation of keratinocyte proliferation nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of tumor necrosis factor production negative regulation of interleukin-2 production negative regulation of viral transcription miRNA mediated inhibition of translation p38MAPK cascade response to starvation regulation of mRNA stability cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of keratinocyte differentiation negative regulation of erythrocyte differentiation mRNA transport positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus negative regulation of cytokine production involved in inflammatory response positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA regulation of keratinocyte apoptotic process negative regulation of polynucleotide adenylyltransferase activity positive regulation of intracellular mRNA localization negative regulation of 3'-UTR-mediated mRNA stabilization positive regulation of gene silencing by miRNA
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support