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Invitrogen

REST Monoclonal Antibody (K92059_15A3)

View all (18) REST antibodies

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REST Monoclonal Antibody (K92059_15A3)

Product Details

MA5-55715

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

K92059_15A3

Immunogen

Recombinant human REST (immunogen range is 331-640).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_3667947

Product Specific Information

Sequence of this protein is as follows: PFKCDQCSYV ASNQHEVTRH ARQVHNGPKP LNCPHCDYKT ADRSNFKKHV ELHVNPRQFN CPVCDYAASK KCNLQYHFKS KHPTCPNKTM DVSKVKLKKT KKREADLPDN ITNEKTEIEQ TKIKGDVAGK KNEKSVKAEK RDVSKEKKPS NNVSVIQVTT RTRKSVTEVK EMDVHTGSNS EKFSKTKKSK RKLEVDSHSL HGPVNDEESS TKKKKKVESK SKNNSQEVPK GDSKVEENKK QNTCMKKSTK KKTLKNKSSK KSSKPPQKEP VEKGSAQMDP PQMGPAPTEA VQKGPVQVEP PPPMEHAQME

Target Information

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box; transcription factor

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Gene Aliases: DFNA27; GINGF5; HGF5; NRSF; WT6; XBR

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UniProt ID: (Human) Q13127

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Entrez Gene ID: (Human) 5978

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome response to hypoxia response to ischemia chromatin remodeling regulation of transcription, DNA-templated response to stress positive regulation of gene expression negative regulation of gene expression negative regulation of aldosterone biosynthetic process somatic stem cell population maintenance positive regulation of programmed cell death negative regulation by host of viral transcription negative regulation of neuron differentiation positive regulation of neuron differentiation regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion negative regulation of neurogenesis neurological system process neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization cardiac muscle cell myoblast differentiation cellular response to electrical stimulus cellular response to glucocorticoid stimulus neuronal stem cell population maintenance modification of synaptic structure positive regulation of stem cell population maintenance negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cortisol biosynthetic process negative regulation of dense core granule biogenesis negative regulation of mesenchymal stem cell differentiation negative regulation of amniotic stem cell differentiation
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