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Invitrogen

Tau Recombinant Rabbit Monoclonal Antibody (PSH05-50)

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Tau Recombinant Rabbit Monoclonal Antibody (PSH05-50)

Product Details

MA5-56494

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:5,000
-

Immunoprecipitation (IP)

1-2 µg
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH05-50

Immunogen

Synthetic peptide within human Tau aa 571-620/758.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3679525

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ31424; FTDP17; map tau; MAPT; MAPT_BigTau; MGC138549; microtubule-associated protein tau 0N4R; microtubule-associated protein tau 1N4R; microtubule-associated protein tau 2N4R; microtubule-associated protein tau BigTau; microtubules; neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHF-tau; PHFtau; tau microtubule binding protein; Tau microtubule-associated protein; Tau-4; Tau5; unnamed protein product

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Gene Aliases: MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt; PHF-tau; pTau; RNPTAU; Tau

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UniProt ID: (Mouse) P10637

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Entrez Gene ID: (Mouse) 17762, (Rat) 29477

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Function(s)
DNA binding enzyme inhibitor activity protein binding microtubule binding tubulin binding SH3 domain binding enzyme binding protein kinase binding heat shock protein binding apolipoprotein binding identical protein binding macromolecular complex binding chaperone binding protein phosphatase 2A binding Hsp90 protein binding lipoprotein particle binding microtubule lateral binding microtubule stabilizing activity
Process(es)
microtubule cytoskeleton organization neuron migration cellular response to DNA damage stimulus axonogenesis synapse assembly response to nutrient learning or memory memory adult walking behavior axo-dendritic transport intrinsic apoptotic signaling pathway in response to oxidative stress response to lead ion regulation of autophagy negative regulation of gene expression negative regulation of mitochondrial membrane potential positive regulation of mitochondrial membrane potential positive regulation of neuron projection development regulation of microtubule polymerization or depolymerization positive regulation of microtubule polymerization neuron projection development negative regulation of intracellular transport positive regulation of superoxide anion generation positive regulation of axon extension microtubule polymerization mitochondrion transport along microtubule intracellular distribution of mitochondria axon extension synapse organization regulation of calcium-mediated signaling mRNA transport protein polymerization protein homooligomerization response to hyperoxia regulation of microtubule-based movement regulation of microtubule cytoskeleton organization negative regulation of mitochondrial fission fibril organization regulation of cellular response to heat positive regulation of long term synaptic depression positive regulation of protein localization to synapse negative regulation of establishment of protein localization to mitochondrion positive regulation of cellular protein localization negative regulation of tubulin deacetylation positive regulation of mesenchymal stem cell migration amyloid fibril formation microtubule-based process female pregnancy response to gamma radiation neuron differentiation response to ethanol response to arsenic-containing substance cellular response to calcium ion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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