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Invitrogen

Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)

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Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)

Product Details

MA5-56516

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE56-35

Immunogen

Recombinant protein within human caspase-1 aa 255-404/404.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.06 mg/mL

Amount

106 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3679543

Target Information

Caspase-1, also known as Interleukin-1β-converting enzyme (ICE), is an inflammatory caspase responsible for processing pro-inflammatory cytokines like IL-1 beta and IL-18, and inducing pyroptosis, a form of programmed cell death. The active form of caspase-1 is a heterotetramer consisting of two p20 and two p10 subunits. The p10 subunit arises from the cleavage of the pro-caspase-1 precursor, which is essential for the enzyme's activation and function. The p12 subunit is a fragment derived from the cleavage of the proenzyme, which is involved in enzyme regulation. Upon activation, caspase-1 cleaves its substrates, leading to the initiation of inflammatory responses and pyroptotic pathways. The regulation of these subunits and their precise activities are crucial for maintaining immune homeostasis and responding to infections and tissue damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CASP-1; caspase 1, apoptosis-related cysteine peptidase; cysteine protease; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45; unnamed protein product

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Gene Aliases: ICE; IL1BC; P45

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UniProt ID: (Human) P29466, (Mouse) P29452

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Entrez Gene ID: (Human) 834, (Mouse) 12362, (Rat) 25166

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Function(s)
endopeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding kinase binding cytokine binding identical protein binding CARD domain binding peptidase activity scaffold protein binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia microglial cell activation plasma membrane repair positive regulation of cytokine production pattern recognition receptor signaling pathway proteolysis inflammatory response osmosensory signaling pathway myoblast fusion memory protein secretion response to xenobiotic stimulus response to bacterium regulation of autophagy programmed cell death protein processing protein autoprocessing protein catabolic process response to lipopolysaccharide positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production response to ATP interleukin-18-mediated signaling pathway defense response to bacterium regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of circadian sleep/wake cycle, non-REM sleep ceramide biosynthetic process regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium protein maturation defense response to virus mitochondrial depolarization membrane hyperpolarization protein poly-ADP-ribosylation pyroptosis interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma programmed necrotic cell death cytokine precursor processing signaling receptor ligand precursor processing AIM2 inflammasome complex assembly pyroptotic cell death positive regulation of NLRP3 inflammasome complex assembly response to paraquat positive regulation of tumor necrosis factor-mediated signaling pathway apoptotic process signal transduction positive regulation of neuron apoptotic process icosanoid biosynthetic process cellular response to mechanical stimulus positive regulation of release of cytochrome c from mitochondria midgut development response to toxic substance lung development animal organ development system development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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