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Invitrogen
ACSL3/ACSL4 Recombinant Rabbit Monoclonal Antibody (HL1941)
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FIGURE: 1 / 1
ACSL3/ACSL4 Antibody (MA5-56584) in WB
Western Blot analysis of ACSL3/ACSL4 using ACSL3/ACSL4 Recombinant Monoclonal Antibody (Product # MA5-56584). 293T, A431, HeLa, and HepG2 whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with ACSL3/ACSL4 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-56584
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1941
Immunogen
Recombinant fragment of human ACSL3 + ACSL4 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
ACSL3 (Acyl-CoA Synthetase Long-Chain Family Member 3) and ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4) are genes that encode enzymes belonging to the acyl-CoA synthetase family. These enzymes play crucial roles in lipid metabolism by catalyzing the activation of long-chain fatty acids through the formation of acyl-CoA. This process is essential for various cellular functions, including lipid biosynthesis, fatty acid degradation, and energy production. ACSL3 is primarily expressed in tissues like the liver and adipose tissue, where it is involved in fatty acid metabolism and lipid storage. ACSL4, on the other hand, is known for its significant role in the brain and in the regulation of inflammatory responses, as well as being implicated in the metabolism of polyunsaturated fatty acids. Dysregulation of ACSL3 and ACSL4 has been linked to several diseases, including metabolic disorders, cancer, and neurological diseases, making them important targets for therapeutic research and drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acyl-CoA synthetase 4; arachidonate--CoA ligase; fatty-acid-Coenzyme A ligase, long-chain 3; fatty-acid-Coenzyme A ligase, long-chain 4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; long-chain-fatty-acid--CoA ligase 3; medium-chain acyl-CoA ligase Acsl3; predicted protein of HQ2194; unnamed protein product
Gene Aliases: ACS3; ACS4; FACL3; FACL4; LACS 3; LACS3; LACS4; MRX63; MRX68; PRO2194; XLID63
UniProt ID: (Human) O95573, (Human) O60488
Entrez Gene ID: (Human) 2181, (Human) 2182
long-chain fatty acid metabolic process
fatty acid metabolic process
neuron differentiation
very-low-density lipoprotein particle assembly
long-chain fatty-acyl-CoA metabolic process
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of Golgi to plasma membrane protein transport
long-chain fatty acid import
positive regulation of secretion
positive regulation of phosphatidylcholine biosynthetic process
lipid metabolic process
fatty acid biosynthetic process
lipid biosynthetic process
positive regulation of cell growth
positive regulation of insulin secretion
negative regulation of prostaglandin secretion
positive regulation of ferroptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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