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Invitrogen

CDK4/CDK6 Recombinant Rabbit Monoclonal Antibody (HL2323)

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Product Details

MA5-56640

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL2323

Immunogen

Recombinant fragment of human CDK4 + CDK6.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3679666

Target Information

CDK4 (Cyclin-Dependent Kinase 4) and CDK6 (Cyclin-Dependent Kinase 6) are crucial regulators of the cell cycle, specifically involved in the transition from the G1 phase to the S phase. These kinases form complexes with D-type cyclins (Cyclin D1, D2, and D3), which are necessary for their activation. Once activated, CDK4 and CDK6 phosphorylate the retinoblastoma protein (RB1), leading to the release of E2F transcription factors that drive the expression of genes required for DNA synthesis and cell cycle progression. Dysregulation of CDK4 and CDK6 activity is a common feature in various cancers, as it can lead to uncontrolled cell proliferation. Consequently, CDK4 and CDK6 have become important targets in cancer therapy, with inhibitors such as palbociclib, ribociclib, and abemaciclib being developed and approved for the treatment of certain types of cancer, particularly hormone receptor-positive breast cancer. These inhibitors work by blocking the kinase activity of CDK4 and CDK6, thereby halting cell cycle progression and reducing tumor growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDK4; cell division protein kinase 4; cell division protein kinase 6; CR2 protein kinase; orf; p34/cdk4; PSK-J3; serine/threonine kinase; serine/threonine-protein kinase PLSTIRE; unnamed protein product

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Gene Aliases: CMM3; Crk2; Crk3; MCPH12; MCPH31; PLSTIRE; PSK-J3

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UniProt ID: (Human) P11802, (Human) Q00534, (Rat) P35426, (Mouse) P30285, (Mouse) Q64261

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Entrez Gene ID: (Human) 1019, (Human) 1021, (Rat) 94201, (Mouse) 12567, (Mouse) 12571, (Rat) 114483

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Function(s)
protein kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding kinase activity cyclin-dependent protein serine/threonine kinase regulator activity cyclin binding protein serine kinase activity FBXO family protein binding macromolecular complex binding nucleotide binding
Process(es)
G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle positive regulation of cell-matrix adhesion type B pancreatic cell development cellular response to DNA damage stimulus signal transduction negative regulation of cell proliferation response to virus regulation of gene expression astrocyte development dentate gyrus development lateral ventricle development hemopoiesis gliogenesis regulation of cell proliferation cell dedifferentiation negative regulation of cell differentiation negative regulation of myeloid cell differentiation regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of osteoblast differentiation negative regulation of cell cycle positive regulation of fibroblast proliferation generation of neurons negative regulation of epithelial cell proliferation regulation of cell cycle regulation of cell motility negative regulation of cellular senescence negative regulation of transcription from RNA polymerase II promoter hematopoietic progenitor cell differentiation Notch signaling pathway positive regulation of gene expression T cell differentiation in thymus hematopoietic stem cell differentiation regulation of hematopoietic stem cell differentiation positive regulation of cell proliferation response to xenobiotic stimulus positive regulation of G2/M transition of mitotic cell cycle regulation of transcription initiation from RNA polymerase II promoter lens development in camera-type eye protein phosphorylation circadian rhythm response to toxic substance organ regeneration response to testosterone positive regulation of apoptotic process positive regulation of translation positive regulation of cell size positive regulation of epithelial cell proliferation response to hyperoxia cellular response to lipopolysaccharide cellular response to interleukin-4 cellular response to polyamine macromolecule cellular response to phorbol 13-acetate 12-myristate cellular response to ionomycin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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