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Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) Recombinant Rabbit Monoclonal Antibody (HL3134)
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FIGURE: 1 / 1
Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) Antibody (MA5-56677) in WB
Western Blot analysis of Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) using Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) Recombinant Monoclonal Antibody (Product # MA5-56677). Non-infected and infected BHK-21 whole cell extracts were separated by 12% SDS-PAGE, and the membrane was blotted with Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-56677
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL3134
Immunogen
Full length of Dengue virus NS4B protein. (strain# Thailand/16681/1984)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
The Dengue Virus Type 2/4 NS4B protein is a non-structural protein that plays a critical role in the replication and pathogenesis of the dengue virus, specifically in serotypes 2 and 4 (DENV-2 and DENV-4). NS4B is a hydrophobic protein that is integrated into the host cell's endoplasmic reticulum membrane, where it contributes to the formation of the viral replication complex. This complex is essential for the synthesis of viral RNA, thereby facilitating the production of new viral particles. NS4B interacts with other non-structural proteins such as NS3 and NS5, and it also plays a role in modulating the host's immune response, helping the virus to evade detection and destruction by the host's immune system. Dengue virus is transmitted to humans primarily through Aedes mosquitoes and causes dengue fever, which can range from mild to severe. Symptoms include high fever, severe headache, retro-orbital pain, joint and muscle pain, rash, and in severe cases, hemorrhagic manifestations or dengue shock syndrome. Due to its essential functions in the viral life cycle and its role in immune evasion, NS4B represents an important target for antiviral drug development. Understanding the structure and function of the NS4B protein in both DENV-2 and DENV-4 serotypes is crucial for designing effective antiviral therapies and for advancing our knowledge of dengue virus biology and pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dengue Virus 2/4; DENV; DENV2/4
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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