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Invitrogen
D4 Dopamine Receptor Recombinant Rabbit Monoclonal Antibody (HL2851)
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FIGURE: 1 / 3
D4 Dopamine Receptor Antibody (MA5-56685) in ICC/IF
Immunocytochemistry analysis of D4 Dopamine Receptor using D4 Dopamine Receptor Recombinant Monoclonal Antibody (Product # MA5-56685) in Mock and transfected 293T cells fixed in ice-cold MeOH for 5 min. D4 Dopamine Receptor antibody diluted at 1:500. Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-56685
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2851
Immunogen
Synthetic peptide encompassing a sequence within the Extracellular domain human of Dopamine Receptor D4. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D(2C) dopamine receptor; Dopamine 4 receptor; dopamine D4 receptor; seven transmembrane helix receptor
Gene Aliases: D4DR
UniProt ID: (Human) P21917
Entrez Gene ID: (Human) 1815
dopamine neurotransmitter receptor activity, coupled via Gi/Go
G-protein coupled receptor activity
adrenergic receptor activity
dopamine neurotransmitter receptor activity
G-protein coupled serotonin receptor activity
protein binding
potassium channel regulator activity
SH3 domain binding
neurotransmitter receptor activity
dopamine binding
identical protein binding
epinephrine binding
norepinephrine binding
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
chemical synaptic transmission
adult locomotory behavior
adult behavior
response to histamine
social behavior
locomotory exploration behavior
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
positive regulation of MAPK cascade
behavioral response to cocaine
behavioral response to ethanol
arachidonic acid secretion
negative regulation of protein secretion
regulation of transport
positive regulation of dopamine uptake involved in synaptic transmission
inhibitory postsynaptic potential
phospholipase C-activating dopamine receptor signaling pathway
adrenergic receptor signaling pathway
G protein-coupled serotonin receptor signaling pathway
regulation of postsynaptic neurotransmitter receptor internalization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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