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Invitrogen
Elastase 3A/3B Recombinant Rabbit Monoclonal Antibody (HL2882)
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FIGURE: 1 / 3
Elastase 3A/3B Antibody (MA5-56692) in WB
Western Blot analysis of Elastase 3A/3B using Elastase 3A/3B Recombinant Monoclonal Antibody (Product # MA5-56692). Mouse pancreas and mouse liver tissue extracts (50 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Elastase 3A/3B antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-56692
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2882
Immunogen
Recombinant fragment of human Elastase 3A + Elastase 3B.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Elastase 3, also known as pancreatic elastase 3 or ELA3, is an enzyme encoded by the CELA3A and CELA3B genes in humans. This enzyme is a member of the serine protease family and is primarily produced in the pancreas. Elastase 3 plays a critical role in the digestive process by breaking down proteins into smaller peptides, specifically targeting elastin, a key protein component of connective tissue. It is secreted into the small intestine, where it aids in the efficient digestion of dietary proteins. Elastase 3 has significant clinical relevance as its levels can be measured in stool samples to assess pancreatic function. Low levels of elastase 3 in the stool are indicative of exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce enough digestive enzymes, leading to malabsorption and nutrient deficiencies. This enzyme is also of interest in research related to various gastrointestinal disorders and pancreatic diseases, including chronic pancreatitis and pancreatic cancer. Understanding the function and regulation of elastase 3 is essential for the development of diagnostic tools and therapeutic strategies for these conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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