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Invitrogen

Cytokeratin Pan Type I/II Recombinant Rabbit Monoclonal Antibody (HL2253)

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Cytokeratin Pan Type I/II Recombinant Rabbit Monoclonal Antibody (HL2253)

Product Details

MA5-56831

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1000-1:10000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:51-1:1000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL2253

Immunogen

Recombinant fragmemt of human Cytokeratin.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3679857

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; 70 kd type II; cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-15; CK-17; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; cytokeratin endo A; cytokeratin endo B; cytokeratin-1; cytokeratin-10; cytokeratin-15; cytokeratin-16; cytokeratin-17; cytokeratin-18; cytokeratin-1B; cytokeratin-2e; cytokeratin-2P; cytokeratin-4; cytokeratin-5; cytokeratin-6A; cytokeratin-7; cytokeratin-8; cytoplasmic intermediate filament protein; cytoskeletal 57 kDa keratin; cytoskeletal protein; embryonic type II keratin 1; EndoA cytokeratin (5' end put.); putative; EndoA' cytokeratin (5' end put.); putative; epidermal keratin 10; epidermal keratin type I; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament protein; intermediate filament protein K16; intermediate filament protein; K7; K1; K1B; K2e; K2P; K6-alpha; K76; K77; keratin 1, type II; keratin 10, type I; keratin 13, type I; keratin 14, type I; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; keratin-10; keratin-15, basic; keratin-15, beta; keratin-2 epidermis; keratin-2e; keratin-6-alpha; KRT1B; KRT5; mK6-alpha; ORF; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I cytoskeletal 15; type II cytoskeletal 1b; type II keratin Kb39; type II keratin subunit protein; type II mesothelial keratin K7; type-II intermediate filament protein; type-II keratin Kb1; type-II keratin Kb2; type-II keratin Kb3; Type-II Keratin Kb39; type-II keratin Kb4; type-II keratin Kb5; type-II keratin Kb6; type-II keratin Kb7; type-II keratin Kb8; type-II keratin Kb9; unnamed protein product

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Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AEI2; BCIE; BIE; CARD2; CK-14; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-4; CK-6A; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EndoA; EndoC; EPPK; FNEPPK; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2e; K3; K4; K5; K6[a]; K6A; K6C; K6D; K7; K76; K77; K8; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT16A; KRT1A; KRT1B; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6a; Krt2-6c; Krt2-7; Krt2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT5A; KRT6C; KRT6D; Krt86; KRTE; MECD2; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC1; PC2; PC3; PCHC1; SCL; Tfip8; TROMA-1; WSN1; WSN2

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UniProt ID: (Human) P04264, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Human) P05783, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Human) P02538, (Human) P08729, (Human) Q01546, (Human) Q7Z794, (Human) P05787, (Mouse) P04104, (Mouse) P02535, (Mouse) P08730, (Mouse) Q61781, (Mouse) Q61414, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Mouse) P05784, (Mouse) P19001, (Mouse) Q3TTY5, (Mouse) P07744, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Mouse) Q3UV17, (Mouse) Q6IFZ6, (Mouse) P11679

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Entrez Gene ID: (Human) 3848, (Human) 3858, (Human) 3860, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3872, (Human) 3875, (Human) 3880, (Human) 3849, (Human) 3850, (Human) 3851, (Human) 3852, (Human) 3853, (Human) 3855, (Human) 51350, (Human) 374454, (Human) 3856, (Mouse) 16678, (Mouse) 16661, (Mouse) 16663, (Mouse) 16664, (Mouse) 16665, (Mouse) 16666, (Mouse) 16667, (Mouse) 16668, (Mouse) 16669, (Mouse) 16681, (Mouse) 16682, (Mouse) 110308, (Mouse) 16687, (Mouse) 110310, (Mouse) 77055, (Mouse) 406220, (Mouse) 16691

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Function(s)
protein binding carbohydrate binding structural constituent of epidermis signaling receptor activity protein heterodimerization activity structural molecule activity structural constituent of cytoskeleton keratin filament binding scaffold protein binding RNA binding structural constituent of muscle cadherin binding involved in cell-cell adhesion macromolecular complex binding cytoskeletal protein binding
Process(es)
keratinization intermediate filament organization morphogenesis of an epithelium cytoskeleton organization epithelial cell differentiation regulation of translation in response to stress positive regulation of cell growth hair follicle morphogenesis positive regulation of translation positive regulation of hair follicle development wound healing negative regulation of keratinocyte differentiation keratinocyte development epidermis development keratinocyte differentiation positive regulation of epidermis development protein heterotetramerization cornification cellular response to calcium ion tongue morphogenesis cellular response to retinoic acid negative regulation of epithelial cell proliferation inflammatory response negative regulation of cell migration hair cycle innate immune response keratinocyte migration establishment of skin barrier Notch signaling pathway response to estrogen sarcomere organization cell differentiation involved in embryonic placenta development response to mechanical stimulus regulation of cell migration regulation of protein localization intermediate filament polymerization intermediate filament bundle assembly positive regulation of keratinocyte differentiation response to radiation positive regulation of cell proliferation cell differentiation killing of cells of other organism defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of entry of bacterium into host cell Wnt signaling pathway intermediate filament cytoskeleton organization tumor necrosis factor-mediated signaling pathway Golgi to plasma membrane protein transport negative regulation of apoptotic process extrinsic apoptotic signaling pathway hepatocyte apoptotic process complement activation, lectin pathway negative regulation of inflammatory response keratinocyte activation keratinocyte proliferation response to hydrostatic pressure response to other organism epithelium development negative regulation of hepatocyte apoptotic process negative regulation of epithelial cell differentiation anatomical structure morphogenesis cell-cell adhesion pigmentation sebaceous gland development response to oxidative stress fibrinolysis regulation of angiogenesis
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