Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

SMO Recombinant Rabbit Monoclonal Antibody (HL2975)

View all (32) SMO antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

MA5-56875

Applications
Tested Dilution
Publications

Western Blot (WB)

1;1,000-1:10,000
-

Flow Cytometry (Flow)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL2975

Immunogen

Recombinant fragment encompassing a sequence within the Intracellular domain of human Smoothened homolog. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3679901

Target Information

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: bent body; candidate receptor for sonic hedgehog; frizzled family member 11; HGNC:11119; Protein Gx; Protein SMOH; Protein smoothened; seven transmembrane helix receptor; smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor

View more View less

Gene Aliases: bnb; CRJS; E130215L21Rik; FZD11; Gx; PHLS; SMO; SMOH; smoothened

View more View less

UniProt ID: (Human) Q99835, (Mouse) P56726

View more View less

Entrez Gene ID: (Human) 6608, (Mouse) 319757

View more View less

Function(s)
cAMP-dependent protein kinase inhibitor activity transmembrane signaling receptor activity G-protein coupled receptor activity patched binding protein binding oxysterol binding protein kinase A catalytic subunit binding protein sequestering activity signal transducer activity drug binding Wnt-protein binding transmembrane signal receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification vasculogenesis osteoblast differentiation in utero embryonic development cell fate specification neural crest cell migration negative regulation of protein phosphorylation hair follicle development heart looping positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation heart morphogenesis determination of left/right asymmetry in lateral mesoderm type B pancreatic cell development protein import into nucleus apoptotic process signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway smoothened signaling pathway determination of left/right symmetry ventral midline determination pattern specification process neuroblast proliferation central nervous system development midgut development cell proliferation positive regulation of cell proliferation tissue development anterior/posterior pattern specification dorsal/ventral pattern formation gene expression regulation of gene expression positive regulation of gene expression negative regulation of gene expression spinal cord dorsal/ventral patterning dentate gyrus development cerebellar cortex morphogenesis thalamus development dorsal/ventral neural tube patterning central nervous system neuron differentiation cerebral cortex development positive regulation of cell migration epithelial cell differentiation negative regulation of epithelial cell differentiation hair follicle morphogenesis protein localization to nucleus multicellular organism growth positive regulation of multicellular organism growth positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth negative regulation of apoptotic process negative regulation of DNA binding positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth astrocyte activation cell development digestive tract development embryonic organ development developmental growth skeletal muscle fiber development smooth muscle tissue development forebrain morphogenesis homeostasis of number of cells within a tissue epithelial cell proliferation positive regulation of epithelial cell proliferation protein stabilization myoblast migration negative regulation of hair follicle development contact inhibition atrial septum morphogenesis mammary gland epithelial cell differentiation epithelial-mesenchymal cell signaling somite development pancreas morphogenesis left/right axis specification cellular response to cholesterol dopaminergic neuron differentiation commissural neuron axon guidance mesenchymal to epithelial transition involved in metanephric renal vesicle formation positive regulation of branching involved in ureteric bud morphogenesis response to inositol regulation of somatic stem cell population maintenance regulation of heart morphogenesis positive regulation of hh target transcription factor activity multicellular organism development smoothened signaling pathway involved in ventral spinal cord patterning smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation axon extension involved in axon guidance detection of cell density by contact stimulus involved in contact inhibition regulation of stem cell population maintenance
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support