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Invitrogen

SAP97 Recombinant Rabbit Monoclonal Antibody (24GB5305)

View all (22) SAP97 antibodies

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SAP97 Recombinant Rabbit Monoclonal Antibody (24GB5305)

Product Details

MA5-57017

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

24GB5305

Immunogen

A synthesized peptide derived from human SAP97 (aa 1-44)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.62 mg/mL

Amount

62 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3680043

Target Information

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; dJ1061C18.1.1; DKFZp761P0818; DKFZp781B0426; DLG1; E-dlg/SAP97; Drosophila discs-large tumor suppressor homologue (synapse associated protein); embryo-dlg/synapse-associated protein 97; presynaptic protein SAP97; synapse-associated protein 97; unnamed protein product

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Gene Aliases: B130052P05Rik; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97

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UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q811D0

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Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383

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Function(s)
guanylate kinase activity phosphoprotein phosphatase activity protein binding cytoskeletal protein binding potassium channel regulator activity kinase binding protein kinase binding phosphatase binding ionotropic glutamate receptor binding ion channel binding cadherin binding binding, bridging L27 domain binding structural constituent of postsynaptic density kinesin binding enzyme binding PDZ domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter endothelial cell proliferation actin filament organization establishment or maintenance of cell polarity chemical synaptic transmission nervous system development regulation of cell shape cortical actin cytoskeleton organization astral microtubule organization protein complex localization regulation of protein localization protein localization to synapse regulation of membrane potential receptor clustering regulation of potassium ion transport positive regulation of potassium ion transport cortical microtubule organization establishment or maintenance of epithelial cell apical/basal polarity GMP metabolic process GDP metabolic process establishment of centrosome localization negative regulation of ERK1 and ERK2 cascade bicellular tight junction assembly protein localization to membrane protein localization to plasma membrane receptor localization to synapse cell-cell adhesion regulation of ventricular cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential regulation of postsynaptic membrane neurotransmitter receptor levels maintenance of postsynaptic density structure neurotransmitter receptor localization to postsynaptic specialization membrane regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport regulation of protein localization to synapse positive regulation of protein localization to plasma membrane regulation of potassium ion import negative regulation of p38MAPK cascade regulation of potassium ion export across plasma membrane protein localization to cell periphery negative regulation of G1/S transition of mitotic cell cycle ureteric bud development branching involved in ureteric bud morphogenesis immunological synapse formation lens development in camera-type eye cell adhesion protein localization positive regulation of cell proliferation positive regulation of gene expression epithelial structure maintenance cerebral cortex development peristalsis positive regulation of actin filament polymerization membrane raft organization regulation of myelination activation of protein kinase activity T cell activation negative regulation of T cell proliferation amyloid precursor protein metabolic process reproductive structure development embryonic skeletal system morphogenesis tissue morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation negative regulation of protein kinase B signaling hard palate development cellular response to brain-derived neurotrophic factor stimulus positive regulation of multicellular organism growth positive regulation of developmental growth
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