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Invitrogen
MEK3/MEK6 Recombinant Rabbit Monoclonal Antibody (24GB310)
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FIGURE: 1 / 3
MEK3/MEK6 Antibody (MA5-57061) in ICC/IF
Immunocytochemical staining of MEK3/MEK6 in HepG2 cells using MEK3/MEK6 Recombinant Monoclonal Antibody (Product # MA5-57061) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; MEK3/MEK6 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57061
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB310
Immunogen
A synthesized peptide derived from human MEK3/MEK6 (aa 300-347)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Colorectal Cancer Metastasis-Suppressed LncRNA; dual specificity mitogen-activated protein kinase kinase 3-like; MAP kinase kinase 3; MAP kinase kinase 6; MAP2K3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; OTTHUMP00000166044; p38 specific mitogen-activated protein kinase; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; stress-activated protein kinase kinase 2; stress-activated protein kinase kinase 3; unnamed protein product
Gene Aliases: CRCMSL; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK3b; MKK6; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3
UniProt ID: (Human) P46734, (Human) P52564, (Mouse) O09110, (Mouse) P70236
Entrez Gene ID: (Human) 5606, (Human) 5608, (Rat) 303200, (Mouse) 26397, (Rat) 114495, (Mouse) 26399
MAPK cascade
osteoblast differentiation
signal transduction
stress-activated protein kinase signaling cascade
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
p38MAPK cascade
signal transduction in response to DNA damage
stress-activated MAPK cascade
regulation of cell cycle
bone development
cellular senescence
negative regulation of cold-induced thermogenesis
regulation of signal transduction by p53 class mediator
regulation of intracellular signal transduction
positive regulation of protein phosphorylation
response to ischemia
protein phosphorylation
response to xenobiotic stimulus
ovulation cycle process
positive regulation of prostaglandin secretion
positive regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
cardiac muscle contraction
cellular response to sorbitol
regulation of cytokine production
inflammatory response
heart development
negative regulation of hippo signaling
cellular response to vascular endothelial growth factor stimulus
positive regulation of blood vessel endothelial cell migration
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
cellular response to lipopolysaccharide
protein maturation
pyroptosis
cellular response to UV-B
NLRP1 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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