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Invitrogen

PP1 alpha/beta Recombinant Rabbit Monoclonal Antibody (24GB1385)

View all (3) PP1 alpha/beta antibodies

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PP1 alpha/beta Recombinant Rabbit Monoclonal Antibody (24GB1385)

Product Details

MA5-57181

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

24GB1385

Immunogen

A synthesized peptide derived from human PP1 alpha/beta (aa 314-327)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.725 mg/mL

Amount

72.5 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3680206

Target Information

PP1 is a major serine/threonine phosphatase that reverses kinase signaling to regulate the cell cycle, glycogen metabolism, transcription, RNA splicing, cytoskeletal dynamics, and synaptic plasticity. The catalytic subunits PP1 alpha (PPP1CA) and PP1 beta (PPP1CB) have near-identical cores, with functional specificity dictated by binding to diverse regulatory/targeting proteins (e.g., RVxF motif partners such as spinophilin, MYPT1, PNUTS) and inhibitors (I-1, I-2). Through these complexes and post-translational control, PP1 precisely dephosphorylates substrates to drive mitotic exit, modulate muscle contractility and metabolism, and tune neuronal signaling. Dysregulation of PP1 alpha/beta contributes to cancer, metabolic and cardiovascular disease, and neurodegeneration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein Li 80p; myosin phosphatase; PP-1A; PP-1B; PPP1CB; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase 1, catalytic subunit, delta isozyme; protein phosphatase 1-beta; protein phosphatase 1-delta; protein phosphatase I alpha subunit (PPPIA) (EC 3.1.3.16); Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1a; protein phosphatase-1d; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; testicular tissue protein Li 155; unnamed protein product

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Gene Aliases: 1200010B19; dism2; HEL-S-80p; MP; NSLH2; PP-1A; PP-1B; PP1A; PP1alpha; PP1B; PP1beta; PP1c; PP1Cbeta; PP1Cdelta; PPP1A; PPP1beta; Ppp1c; PPP1CD

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UniProt ID: (Human) P62136, (Human) P62140, (Rat) P62138, (Mouse) P62137, (Mouse) P62141, (Rat) P62142

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Entrez Gene ID: (Human) 5499, (Human) 5500, (Rat) 24668, (Mouse) 19045, (Mouse) 19046, (Rat) 25594

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Function(s)
phosphoprotein phosphatase activity protein serine/threonine phosphatase activity iron ion binding protein binding protein phosphatase 1 binding hydrolase activity phosphatase activity ribonucleoprotein complex binding macromolecular complex binding transition metal ion binding cadherin binding involved in cell-cell adhesion RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity myosin phosphatase activity protein kinase binding myosin-light-chain-phosphatase activity
Process(es)
promoter clearance from RNA polymerase II promoter regulation of glycogen biosynthetic process regulation of glycogen catabolic process protein dephosphorylation response to lead ion lung development circadian regulation of gene expression positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of transcription elongation from RNA polymerase II promoter regulation of circadian rhythm entrainment of circadian clock by photoperiod telomere maintenance in response to DNA damage positive regulation of glycogen biosynthetic process branching morphogenesis of an epithelial tube protein stabilization cell-cell adhesion positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled positive regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell adhesion regulation of translational initiation in response to stress positive regulation of Ras protein signal transduction regulation of canonical Wnt signaling pathway MAPK cascade telomere maintenance glycogen metabolic process transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter regulation of translation negative regulation of triglyceride catabolic process double-strand break repair via alternative nonhomologous end joining
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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