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Invitrogen

FGF2 Recombinant Rabbit Monoclonal Antibody (24GB4420)

View all (41) FGF2 antibodies

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FGF2 Recombinant Rabbit Monoclonal Antibody (24GB4420)

Product Details

MA5-57400

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

24GB4420

Immunogen

Recombinant protein of human FGF2 (aa 143-288)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Amount

70 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3680425

Target Information

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 18 kd basic fibroblast growth factor; 21 kd basic fibroblast growth factor (ctg start codon; put.); putative; basic fibroblast growth factor; basic fibroblast growth factor (ctg start codon); putative; basic fibroblast growth factor bFGF; FGF; fgf basic; FGF-b; FGF2; Fibroblast growth factor; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; H-FGF-b-147; H-FGF-b-154; heparin-binding growth factor 2; M-FGF-b; prostatropin

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Gene Aliases: BFGF; FGF-2; FGFB; HBGF-2

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UniProt ID: (Human) P09038

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Entrez Gene ID: (Human) 2247

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Function(s)
fibroblast growth factor receptor binding cytokine activity integrin binding protein binding growth factor activity chemokine binding chemoattractant activity identical protein binding histone H3K9me2/3 reader activity receptor-receptor interaction
Process(es)
branching involved in ureteric bud morphogenesis positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis chromatin organization chemotaxis signal transduction Ras protein signal transduction nervous system development positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway embryo development ending in birth or egg hatching organ morphogenesis positive regulation of endothelial cell migration negative regulation of gene expression negative regulation of fibroblast migration growth factor dependent regulation of skeletal muscle satellite cell proliferation neurogenesis hyaluronan catabolic process regulation of cell migration paracrine signaling negative regulation of fibroblast growth factor receptor signaling pathway wound healing positive regulation of cell fate specification positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration response to ethanol regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter behavioral response to ethanol embryonic morphogenesis positive regulation of smooth muscle cell proliferation stem cell development positive chemotaxis release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling positive regulation of cardiac muscle cell proliferation chondroblast differentiation angiogenesis involved in coronary vascular morphogenesis negative regulation of wound healing positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus stem cell proliferation regulation of cell migration involved in sprouting angiogenesis positive regulation of cell migration involved in sprouting angiogenesis positive regulation of lens fiber cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of sprouting angiogenesis response to wortmannin positive regulation of vascular smooth muscle cell proliferation positive regulation of epithelial tube formation regulation of morphogenesis of an epithelium positive regulation of blood vessel branching positive regulation of vascular endothelial cell proliferation regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis
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