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Invitrogen
NCAPD2 Recombinant Rabbit Monoclonal Antibody (24GB75)
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FIGURE: 1 / 4
NCAPD2 Antibody (MA5-57514) in ICC/IF
Immunocytochemical staining of NCAPD2 in HepG2 cells using NCAPD2 Recombinant Monoclonal Antibody (Product # MA5-57514) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; NCAPD2 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57514
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB75
Immunogen
A synthesized peptide derived from human CNAP1 (aa 100-200)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.5 mg/mL
Amount
150 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromosome condensation-related SMC-associated protein 1; chromosome-associated protein D2; KIAA0159; mCAP-D2; unnamed protein product; XCAP-D2 homolog
Gene Aliases: 2810406C15Rik; 2810465G24Rik; CAP-D2; CNAP1; hCAP-D2; MCPH21; mKIAA0159; RGD1562596
UniProt ID: (Human) Q15021, (Mouse) Q8K2Z4
Entrez Gene ID: (Human) 9918, (Rat) 362438, (Mouse) 68298
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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