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Invitrogen
IL-6 Receptor Recombinant Rabbit Monoclonal Antibody (9S8Q5)
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FIGURE: 1 / 1
IL-6 Receptor Antibody (MA5-57953) in WB
Western blot analysis of IL-6 Receptor in Mouse spleen lysates (25 µg/lane). Samples were incubated overnight at 4°C with IL-6 Receptor Recombinant Monoclonal Antibody (Product # MA5-57954) using a dilution of 1:1, 000. Followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) Secondary Antibody at 1:10,000 dilution. Blocking buffer: 3% nonfat dry milk in TBST; Exposure: 90 seconds.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57953
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9S8Q5
Immunogen
Recombinant Protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.07 mg/mL
Amount
21.4 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: LVLGSCRALE VANGTVTSLP GATVTLICPG KEAAGNVTIH WVYSGSQNRE WTTTGNTLVL RDVQLSDTGD YLCSLNDHLV GTVPLLVDVP PEEPKLSCFR KNPLVNAICE WRPSSTPSPT TKAVLFAKKI NTTNGKSDFQ VPCQYSQQLK SFSCQVEILE GDKVYHIVSL CVANSVGSKS SHNEAFHSLK MVQPDPPANL VVSAIPGRPR WLKVSWQHPE TWDPSYYLLQ FQLRYRPVWS KEFTVLLLPV AQYQCVIHDA LRGVKHVVQV RGKEELDLGQ WSEWSPEVTG TPWIAEPRTT PAGILWNPTQ VSVEDSANHE DQYESSTEAT SVLAPVQE
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; ILN; Interleukin; MGC104991; unnamed protein product
Gene Aliases: CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r
UniProt ID: (Mouse) P22272
Entrez Gene ID: (Mouse) 16194
JAK-STAT cascade
positive regulation of cell proliferation
vascular endothelial growth factor production
cytokine-mediated signaling pathway
endocrine pancreas development
developmental process
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine
autocrine signaling
interleukin-11-mediated signaling pathway
positive regulation of MAPK cascade
developmental growth
positive regulation of smooth muscle cell proliferation
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
positive regulation of glomerular mesangial cell proliferation
T-helper 17 cell lineage commitment
receptor signaling pathway via STAT
positive regulation of platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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