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Invitrogen
DNA-PK Recombinant Rabbit Monoclonal Antibody (8O7U9)
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Product Details
MA5-58073
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8O7U9
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 4021-4120 of human DNA-PKcs (NP_008835.5).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.26 mg/mL
Amount
25.2 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: LKKGGSWIQE INVAEKNWYP RQKICYAKRK LAGANPAVIT CDELLLGHEK APAFRDYVAV ARGSKDHNIR AQEPESGLSE ETQVKCLMDQ ATDPNILGRT
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-activated protein kinase catalytic subunit; DNA-PK catalytic subunit; hyper-radiosensitivity of murine scid mutation, complementing 1; p460; protein kinase, DNA-activated, catalytic polypeptide; ser-473 kinase; unnamed protein product
Gene Aliases: DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1; HYRC; HYRC1; IMD26; p350; S473K; XRCC7
UniProt ID: (Human) P78527
Entrez Gene ID: (Human) 5591
double-stranded DNA binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
DNA-dependent protein kinase activity
protein binding
kinase activity
enzyme binding
protein domain specific binding
U3 snoRNA binding
histone H2AXS139 kinase activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
protein serine kinase activity
maturation of 5.8S rRNA
telomere maintenance
negative regulation of protein phosphorylation
activation of innate immune response
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
chromatin remodeling
protein phosphorylation
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
telomere capping
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
mitotic G1 DNA damage checkpoint
cellular response to insulin stimulus
immunoglobulin V(D)J recombination
small-subunit processome assembly
protein modification process
regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of lymphocyte differentiation
positive regulation of erythrocyte differentiation
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
regulation of smooth muscle cell proliferation
regulation of epithelial cell proliferation
regulation of cellular response to stress
double-strand break repair via alternative nonhomologous end joining
negative regulation of cGAS/STING signaling pathway
regulation of hematopoietic stem cell differentiation
positive regulation of platelet formation
positive regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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