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Invitrogen

CX3CL1 (Quetmolimab Biosimilar) Recombinant Human Monoclonal Antibody

View all (33) CX3CL1 antibodies

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Product Details

MA5-58289

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG2SA

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3681309

Product Specific Information

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

This product is a Humanized mouse antibody.

Target Information

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small-inducible cytokine D1; unnamed protein product

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Gene Aliases: ABCD-3; C3Xkine; CXC3; CXC3C; fractalkine; neurotactin; NTN; NTT; SCYD1

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UniProt ID: (Human) P78423

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Entrez Gene ID: (Human) 6376

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Function(s)
receptor binding integrin binding protein binding chemokine activity CX3C chemokine receptor binding chemoattractant activity CXCR1 chemokine receptor binding CCR chemokine receptor binding
Process(es)
microglial cell activation positive regulation of cell-matrix adhesion positive regulation of neuroblast proliferation leukocyte migration involved in inflammatory response response to ischemia chemotaxis defense response inflammatory response immune response cell adhesion G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation negative regulation of cell-substrate adhesion positive regulation of neuron projection development neuron remodeling cytokine-mediated signaling pathway positive regulation of cell migration negative regulation of cell migration leukocyte chemotaxis regulation of lipopolysaccharide-mediated signaling pathway positive regulation of actin filament bundle assembly negative regulation of interleukin-1 alpha production negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production integrin activation autocrine signaling negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity eosinophil chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of neurogenesis leukocyte adhesive activation positive chemotaxis positive regulation of calcium-independent cell-cell adhesion positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling cell chemotaxis microglial cell proliferation antimicrobial humoral immune response mediated by antimicrobial peptide neuron cellular homeostasis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cell-cell adhesion synapse pruning negative regulation of hippocampal neuron apoptotic process negative regulation of glutamate receptor signaling pathway negative regulation of microglial cell activation positive regulation of microglial cell migration negative regulation of neuron migration negative regulation of apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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