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Invitrogen
IL-18 (Aletekutug Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-58331
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This product is a Humanized rat antibody.
Target Information
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine; iboctadekin; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL18; ILN; interferon-gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; Interleukin18; MGC12320
Gene Aliases: IGIF; IL-18; IL-1g; IL1F4
UniProt ID: (Human) Q14116
Entrez Gene ID: (Human) 3606
angiogenesis
negative regulation of T-helper 1 type immune response
inflammatory response
immune response
cell surface receptor signaling pathway
cell-cell signaling
positive regulation of macrophage derived foam cell differentiation
cytokine-mediated signaling pathway
regulation of cell adhesion
sleep
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-13 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
positive regulation of tissue remodeling
interleukin-18-mediated signaling pathway
T-helper 1 type immune response
type 2 immune response
positive regulation of activated T cell proliferation
positive regulation of tyrosine phosphorylation of STAT protein
cholesterol homeostasis
T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NK T cell proliferation
positive regulation of protein kinase B signaling
establishment of skin barrier
triglyceride homeostasis
cellular response to lipopolysaccharide
positive regulation of cold-induced thermogenesis
positive regulation of neuroinflammatory response
positive regulation of NIK/NF-kappaB signaling
positive regulation of T-helper 1 cell cytokine production
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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