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Invitrogen
FLT3 (CD135) (Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-58585
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term IMC-EB10.
Target Information
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD135 antigen; fetal liver kinase 2; FL cytokine receptor; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; RP11-153M24.3; stem cell tyrosine kinase 1
Gene Aliases: CD135; FLK-2; FLK2; STK1
UniProt ID: (Human) P36888
Entrez Gene ID: (Human) 2322
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
cytokine receptor activity
vascular endothelial growth factor-activated receptor activity
protein binding
ATP binding
growth factor binding
glucocorticoid receptor binding
macromolecular complex binding
phosphatidylinositol 3-kinase activator activity
leukocyte homeostasis
myeloid progenitor cell differentiation
pro-B cell differentiation
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis
B cell differentiation
common myeloid progenitor cell proliferation
vascular endothelial growth factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
lymphocyte proliferation
protein autophosphorylation
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
dendritic cell differentiation
liver regeneration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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