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Invitrogen
Nogo-A/B (Ozanezumab Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-58731
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This product is a Humanized mouse antibody.
Target Information
Nogo-B is a novel myelin-associated, intermediate-length splice variant of Nogo belonging to the reticulon family. It is a multidomain neurite growth inhibitory protein containing several discrete regions with growth inhibitory functions and is a component of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Nogo-B along with NGBR mediated chemotaxis in HUVECs and induced tube formation in 3-dimensional cultures. It is mostly found in intact blood vessels, smooth muscle cells, and endothelial cell, with its N terminus oriented extracellularly and is a regulator of vascular homeostasis and remodeling. It plays an important role in sporadic and familial amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASY; foocen; Human NogoA; MGC116054; My043 protein; neurite growth inhibitor 220; neurite outgrowth inhibitor; neuroendocrine-specific protein C homolog; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; reticulon; reticulon 5; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product
Gene Aliases: ASY; Nbla00271; Nbla10545; NI220/250; NOGO; NOGOA; NOGOB; NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
UniProt ID: (Human) Q9NQC3
Entrez Gene ID: (Human) 57142
leukocyte migration involved in inflammatory response
apoptotic process
endoplasmic reticulum organization
axonal fasciculation
brain development
positive regulation of epithelial cell migration
cerebral cortex radial glia guided migration
central nervous system vasculogenesis
neuron differentiation
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of mammary gland epithelial cell proliferation
positive regulation of toll-like receptor 9 signaling pathway
positive regulation of Rac protein signal transduction
cell migration involved in vasculogenesis
regulation of apoptotic process
positive regulation of angiogenesis
modulation of synaptic transmission
protein stabilization
nuclear pore complex assembly
positive regulation of protein kinase B signaling
regulation of nervous system development
positive regulation of macrophage cytokine production
protein localization to lysosome
cellular response to hypoxia
endoplasmic reticulum tubular network organization
endoplasmic reticulum tubular network assembly
cellular sphingolipid homeostasis
cell adhesion involved in sprouting angiogenesis
regulation of postsynapse assembly
negative regulation of beta-amyloid formation
positive regulation of neutrophil migration
positive regulation of macrophage migration
positive regulation of protein localization to endoplasmic reticulum
positive regulation of ERBB3 signaling pathway
positive regulation of artery morphogenesis
endoplasmic reticulum tubular network membrane organization
regulation of branching morphogenesis of a nerve
positive regulation of hepatocyte proliferation
negative regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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