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Invitrogen
PD-L1/TGF beta (Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-60149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL once reconstituted
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Tqb2858.
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
The TGF-beta (transforming growth factor beta) gene encodes a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGF-beta acts as a cellular switch to regulate immune responses, cell growth, apoptosis, and cellular homeostasis. The human TGF-beta family comprises three isoforms: TGF-beta 1, TGF-beta 2, and TGF-beta 3, encoded by the genes TGFB1, TGFB2, and TGFB3 located on chromosomes 19q13, 1q41, and 14q24 respectively. These genes produce inactive precursor proteins, which are further processed into active forms. The mature TGF-beta protein is a dimer formed by two identical peptide chains linked by disulfide bonds. It signals through serine/threonine kinase receptors and downstream SMAD transcription factors, leading to the regulation of target gene expression. TGF-beta is crucial for tissue homeostasis and immune system modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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