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Invitrogen
Shiga toxin 2 (Setoxaximab Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-60167
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Target Information
Shiga toxin 2 (Stx2) is another variant of the Shiga toxins produced by certain strains of Shigella dysenteriae and Escherichia coli. Structurally, like Shiga toxin 1, Stx2 is an AB5 toxin composed of one A subunit and five B subunits. The A subunit has an N-glycosidase activity that disrupts protein synthesis by cleaving a specific adenine residue from the 28S rRNA of the 60S ribosomal subunit, leading to cell death. The B subunits form a pentamer that binds to the glycosphingolipid receptor Gb3 (globotriaosylceramide) on the surface of host cells, facilitating the entry of the A subunit into the cells. Functionally, Stx2 is highly cytotoxic and plays a crucial role in the pathogenicity of the bacterial strains that produce it, leading to severe diseases such as hemolytic uremic syndrome (HUS), which is characterized by acute kidney failure, hemolytic anemia, and thrombocytopenia. Stx2 is known to be more potent and associated with more severe disease outcomes compared to Stx1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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