Search
Invitrogen
HDAC3 Recombinant Rabbit Monoclonal Antibody (4D4)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
HDAC3 Antibody (MA5-60648) in IHC (P)
Immunohistochemistry analysis of HDAC3 in paraffin-embedded human endometrial cancer. Samples were incubated with HDAC3 Recombinant Monoclonal antibody (Product # MA5-60648) using a dilution of 1:100 followed by detection with Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0).... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-60648
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
4D4
Immunogen
A synthesized peptide derived from human HDAC3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HDAC3; protein deacetylase HDAC3; protein deacylase HDAC3; SMAP45
Gene Aliases: HD3; KDAC3; RPD3; RPD3-2
UniProt ID: (Human) O15379
Entrez Gene ID: (Human) 8841
transcription corepressor binding
DNA binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
enzyme binding
cyclin binding
chromatin DNA binding
protein deacetylase activity
histone deacetylase binding
NF-kappaB binding
histone isonicotinyllysine deisonicotinylase activity
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
protein decrotonylase activity
histone decrotonylase activity
protein de-2-hydroxyisobutyrylase activity
protein lysine delactylase activity
negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
in utero embryonic development
positive regulation of protein phosphorylation
chromatin organization
protein deacetylation
epidermis development
gene expression
negative regulation of myotube differentiation
positive regulation of protein ubiquitination
regulation of protein stability
positive regulation of TOR signaling
circadian regulation of gene expression
regulation of gene expression, epigenetic
positive regulation of protein import into nucleus
regulation of circadian rhythm
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
spindle assembly
negative regulation of transcription initiation from RNA polymerase II promoter
random inactivation of X chromosome
establishment of skin barrier
cellular response to fluid shear stress
positive regulation of cold-induced thermogenesis
DNA repair-dependent chromatin remodeling
positive regulation of ferroptosis
cornified envelope assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support