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Invitrogen
IL2RG Recombinant Human Monoclonal Antibody (6F3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-60742
Product Specifications
Species Reactivity
Cynomolgus monkey,
Human
Host/Isotype
Human
/ IgG4
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
6F3
Immunogen
Recombinant Human IL2RG protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD132 antigen; common cytokine receptor gamma chain; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL2R gamma; interleukin 2 receptor, gamma; nonfunctional common cytokine receptor gamma chain; unnamed protein product
Gene Aliases: CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1
UniProt ID: (Human) P31785
Entrez Gene ID: (Human) 3561, (Cynomolgus monkey) 102144912
leukocyte homeostasis
immune response
signal transduction
JAK-STAT cascade
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
cellular homeostasis
lymphocyte differentiation
natural killer cell activation
interleukin-15-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of T cell differentiation
positive regulation of phagocytosis
positive regulation of leukocyte proliferation
negative regulation of Fas signaling pathway
positive regulation of leukocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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