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Invitrogen
Cathepsin 1/7 Monoclonal Antibody (228905)
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Product Details
MA5-60991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
228905
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin 7/Cathepsin 1, Ala18-Leu331
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Cathepsins are a family of proteases, and Cathepsins B and L (sometimes referred to as Cathepsin 1 and Cathepsin 7, respectively) are notable members of this group. These enzymes are primarily involved in the degradation of proteins within lysosomes, contributing to cellular turnover and homeostasis. Cathepsin B, encoded by the CTSB gene, is a cysteine protease that participates in various physiological processes, including protein catabolism, antigen processing, and apoptosis. Similarly, Cathepsin L, encoded by the CTSL gene, also functions as a cysteine protease and is crucial for normal cellular functions, such as tissue remodeling and immune responses. Dysregulation of these enzymes has been implicated in numerous pathological conditions, including cancer, neurodegenerative diseases, and inflammatory disorders. Understanding the roles and regulation of Cathepsin B and Cathepsin L can provide valuable insights into disease mechanisms and potential therapeutic interventions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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