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Invitrogen
GATA2 Monoclonal Antibody (527530)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61085
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
527530
Immunogen
E. coli-derived recombinant human GATA-2, Ala15-Thr279
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ45948; MGC2306; unnamed protein product
Gene Aliases: DCML; Gata-2; IMD21; MONOMAC; NFE1B
UniProt ID: (Human) P23769, (Mouse) O09100
Entrez Gene ID: (Human) 2624, (Mouse) 14461
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
C2H2 zinc finger domain binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cytosolic calcium ion concentration
anatomical structure morphogenesis
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
response to lipid
eosinophil fate commitment
positive regulation of mast cell degranulation
positive regulation of blood vessel endothelial cell migration
cell fate commitment
fat cell differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
system development
positive regulation of phagocytosis
regulation of developmental process
positive regulation of phagocytosis, engulfment
vascular wound healing
positive regulation of cell migration involved in sprouting angiogenesis
cochlea development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
negative regulation of endothelial cell apoptotic process
urogenital system development
cell fate determination
embryonic placenta development
regulation of primitive erythrocyte differentiation
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
neuron differentiation
somatic stem cell population maintenance
inner ear morphogenesis
negative regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
cell maturation
animal organ development
neuron fate commitment
homeostasis of number of cells within a tissue
regulation of multicellular organismal process
definitive hemopoiesis
semicircular canal development
GABAergic neuron differentiation
regulation of forebrain neuron differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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