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Invitrogen
GATA4 Monoclonal Antibody (532025)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61187
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
532025
Immunogen
E. coli-derived recombinant human GATA-4, Met27-Ser212
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
GATA4 is a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in the gene encoding GATA4 have been associated with cardiac septal defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GAT4; GATA-binding factor 4; MGC126629; putative; unnamed protein product
Gene Aliases: ASD2; TACHD; TOF; VSD1
UniProt ID: (Human) P43694
Entrez Gene ID: (Human) 2626
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
protein kinase binding
sequence-specific DNA binding
NFAT protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
co-SMAD binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
heart looping
heart morphogenesis
atrioventricular node development
aortic valve morphogenesis
atrioventricular valve formation
endocardial cushion development
cardiac ventricle morphogenesis
cardiac right ventricle morphogenesis
cardiac septum development
ventricular septum development
atrial septum primum morphogenesis
atrial septum secundum morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell-cell signaling
endoderm development
heart development
male gonad development
response to xenobiotic stimulus
response to mechanical stimulus
anatomical structure morphogenesis
tissue development
negative regulation of autophagy
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
cell differentiation
positive regulation of BMP signaling pathway
response to retinoic acid
response to vitamin A
embryonic heart tube anterior/posterior pattern specification
atrioventricular canal development
wound healing
negative regulation of apoptotic process
cell fate commitment
positive regulation of angiogenesis
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic foregut morphogenesis
cardiac muscle cell differentiation
transdifferentiation
atrial septum morphogenesis
intestinal epithelial cell differentiation
cardiac muscle tissue regeneration
cell growth involved in cardiac muscle cell development
cellular response to glucose stimulus
regulation of cardiac muscle cell contraction
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of connective tissue replacement
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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