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Invitrogen
pro-MMP7 Monoclonal Antibody (377313)
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Product Details
MA5-61236
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
377313
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MMP-7, Leu18-Leu264
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Pro-MMP7 (pro-Matrix Metallopeptidase 7) is a gene that encodes the inactive precursor of MMP7, an enzyme belonging to the matrix metalloproteinase (MMP) family. MMP7, also known as matrilysin, is involved in the breakdown of extracellular matrix components, which is crucial for various physiological processes such as tissue remodeling, wound healing, and embryonic development. Unlike other MMPs, MMP7 has a broad substrate specificity and can degrade a variety of extracellular matrix proteins, including casein, gelatins, fibronectin, and proteoglycans. The activation of pro-MMP7 to its active form is tightly regulated, often requiring proteolytic cleavage. Dysregulation of MMP7 activity has been implicated in pathological conditions such as cancer, where it can promote tumor invasion and metastasis, as well as in inflammatory diseases. Understanding the regulation and function of pro-MMP7 is essential for developing therapeutic strategies aimed at modulating its activity in various diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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