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Invitrogen
pro-GDF3 Monoclonal Antibody (356613)
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Product Details
MA5-61341
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
356613
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse GDF-3 Propeptide, Ser23-Lys250
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Pro-GDF3, or pro-growth differentiation factor 3, is the precursor form of GDF3, a member of the transforming growth factor-beta (TGF-beta) superfamily. GDF3 is involved in various biological processes including embryonic development, cell differentiation, and regulation of adipose tissue homeostasis. Pro-GDF3 undergoes proteolytic processing to become the mature, active form that can then bind to its receptors and initiate signaling pathways. GDF3 plays a critical role in early embryogenesis, particularly in the formation of the mesoderm and endoderm, and in maintaining the pluripotency of embryonic stem cells. Additionally, GDF3 has been implicated in metabolic regulation and in the pathogenesis of obesity and type 2 diabetes. Abnormal expression or mutations in the GDF3 gene can lead to developmental disorders and contribute to disease states. As a result, pro-GDF3 and its mature form are of significant interest in developmental biology, regenerative medicine, and metabolic disease research, offering potential targets for therapeutic intervention.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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