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Invitrogen
SIRT2 Monoclonal Antibody (506611)
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Product Details
MA5-61429
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
506611
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Sirtuin 2/SIRT2, Ala2-Gln389
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; regulatory protein SIR2 homolog 2; silent information regulator 2; SIR2-h; SIR2-like protein 2; sir2-related protein type 2; sir2-related protein type 2; sirtuin type 2; NAD-dependent deacetylase sirtuin-2; silent information regulator 2; SIR2-like protein 2; regulatory protein SIR2; sirtuin type 2; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog
Gene Aliases: SIR2; SIR2L; SIR2L2
UniProt ID: (Human) Q8IXJ6
Entrez Gene ID: (Human) 22933
chromatin binding
NAD+ ADP-ribosyltransferase activity
histone deacetylase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity
protein deacetylase activity
NAD-dependent protein deacetylase activity
histone acetyltransferase binding
histone deacetylase binding
tubulin deacetylase activity
ubiquitin binding
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD binding
NAD+ binding
histone methacryllysine demethacrylase activity
histone benzoyllysine debenzoylase activity
DNA-binding transcription factor binding
NAD-dependent protein demyristoylase activity
NAD-dependent protein depalmitoylase activity
NAD-dependent protein lysine deacylase activity
protein ADP-ribosylase activity
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
chromatin remodeling
protein deacetylation
mitotic nuclear envelope reassembly
regulation of exit from mitosis
negative regulation of autophagy
negative regulation of peptidyl-threonine phosphorylation
lipid catabolic process
substantia nigra development
myelination in peripheral nervous system
heterochromatin assembly
telomeric heterochromatin assembly
regulation of myelination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
peptidyl-lysine deacetylation
regulation of gene expression, epigenetic
negative regulation of protein catabolic process
regulation of phosphorylation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
post-translational protein modification
negative regulation of fat cell differentiation
positive regulation of fatty acid biosynthetic process
positive regulation of meiotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of lipid biosynthetic process
negative regulation of developmental process
regulation of multicellular organismal process
regulation of cell cycle
response to redox state
positive regulation of cell division
positive regulation of attachment of spindle microtubules to kinetochore
cellular response to caloric restriction
negative regulation of oligodendrocyte progenitor proliferation
cellular response to hypoxia
cellular response to epinephrine stimulus
tubulin deacetylation
positive regulation of execution phase of apoptosis
positive regulation of oocyte maturation
negative regulation of satellite cell differentiation
negative regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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