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Invitrogen
pro-IL-33 Monoclonal Antibody (518017)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61510
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
518017
Immunogen
E. coli-derived recombinant mouse IL-33 Propeptide, Met1-Leu108
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Pro-IL-33 is the precursor form of interleukin-33 (IL-33), a cytokine that plays an essential role in the immune system, particularly in the regulation of inflammatory and immune responses. IL-33 is a member of the IL-1 family and is produced by various cell types, including epithelial cells, endothelial cells, and fibroblasts. In its precursor form, pro-IL-33 is biologically active and can be cleaved by caspases or other proteases to generate the mature, active cytokine. IL-33 functions by binding to its receptor, ST2 (IL1RL1), on the surface of target cells, which include a variety of immune cells such as Th2 cells, mast cells, and group 2 innate lymphoid cells (ILC2s). This interaction leads to the activation of signaling pathways that promote the production of Th2-associated cytokines, contributing to the immune response against infections and playing a role in allergic inflammation. Elevated levels of IL-33 have been associated with various inflammatory and autoimmune diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). Due to its significant role in modulating immune responses, pro-IL-33 is a critical target for research aimed at developing new treatments for inflammatory and autoimmune conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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