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Invitrogen
C. botulinum BoNT-D Light Chain Monoclonal Antibody (695004)
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Product Details
MA5-61617
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
695004
Immunogen
E. coli-derived recombinant C. botulinum BoNT-D Light Chain, Thr2-Ser428
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
The gene encoding the BoNT-D Light Chain is part of the botulinum neurotoxin type D (BoNT-D) produced by Clostridium botulinum, a gram-positive, spore-forming bacterium. BoNT-D is one of the seven serotypes of botulinum toxin, which are highly potent neurotoxins causing botulism, a severe paralytic illness. The BoNT-D toxin is synthesized as a single polypeptide and subsequently cleaved into a heavy chain and a light chain. The light chain (LC) of BoNT-D is a zinc-dependent endopeptidase responsible for the neurotoxin's enzymatic activity. It specifically cleaves synaptobrevin, a SNARE protein essential for the fusion of synaptic vesicles with the presynaptic membrane, thereby inhibiting the release of acetylcholine at the neuromuscular junction. This inhibition leads to flaccid paralysis, the hallmark of botulism. Understanding the structure and function of the BoNT-D light chain is crucial for the development of antitoxins and therapeutic interventions. Additionally, research into this and other botulinum neurotoxins has broad implications, ranging from public health and biodefense to potential medical applications in treating muscle disorders and other conditions involving neurotransmission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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