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Invitrogen
Endothelin A Receptor Monoclonal Antibody (485711)
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Product Details
MA5-61682
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
485711
Immunogen
NS0 mouse myeloma cell line transfected with human EDRNA
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelin A; endothelin receptor subtype A; Endothelin receptor type A; Endothelin-1 receptor; endothelin-1-specific receptor; ET-A; ET-AR; ET-AR delta 3-4; ET-AR delta 4; G protein-coupled receptor; G-protein coupled receptor; unnamed protein product
Gene Aliases: EDNRA; ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA
UniProt ID: (Human) P25101
Entrez Gene ID: (Human) 1909
mitotic cell cycle
angiogenesis
patterning of blood vessels
response to hypoxia
in utero embryonic development
blood vessel remodeling
response to amphetamine
regulation of heart rate
heart process
glomerular filtration
cardiac chamber formation
left ventricular cardiac muscle tissue morphogenesis
atrial cardiac muscle tissue development
cardiac neural crest cell migration involved in outflow tract morphogenesis
noradrenergic neuron differentiation
cellular calcium ion homeostasis
smooth muscle contraction
mitochondrion organization
signal transduction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
axon guidance
heart development
respiratory gaseous exchange
regulation of blood pressure
cell proliferation
response to wounding
gene expression
regulation of glucose transport
neural crest cell development
neural crest cell differentiation
neural crest cell fate commitment
artery smooth muscle contraction
vascular smooth muscle contraction
neuron remodeling
heparin metabolic process
thyroid gland development
neuron projection development
glomerulus development
cellular response to oxidative stress
embryonic heart tube development
aorta development
vasoconstriction
norepinephrine metabolic process
middle ear morphogenesis
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to human chorionic gonadotropin stimulus
developmental pigmentation
enteric nervous system development
sympathetic nervous system development
axon extension
embryonic skeletal system development
neuromuscular process
sodium ion homeostasis
canonical Wnt signaling pathway
head development
face development
axonogenesis involved in innervation
establishment of endothelial barrier
pharyngeal arch artery morphogenesis
renal sodium ion absorption
calcium ion transmembrane transport
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
protein transmembrane transport
glomerular endothelium development
glomerular visceral epithelial cell differentiation
endothelin receptor signaling pathway
endothelin receptor signaling pathway involved in heart process
renal albumin absorption
vascular smooth muscle cell development
mesenchymal cell apoptotic process
cellular response to toxic substance
sympathetic neuron axon guidance
cAMP/PKA signal transduction
semaphorin-plexin signaling pathway involved in axon guidance
glomerular visceral epithelial cell apoptotic process
meiotic cell cycle process involved in oocyte maturation
cranial skeletal system development
response to acetylcholine
regulation of protein localization to cell leading edge
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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