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Invitrogen
Nogo-B Monoclonal Antibody (523808)
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Product Details
MA5-61691
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
523808
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Nogo-B., Met1-Ile183 (predicted)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Nogo-B is a member of the reticulon-4 (RTN4) family of proteins, primarily localized to the endoplasmic reticulum and expressed in many tissues, especially vascular endothelial and smooth muscle cells. It plays a key role in regulating vascular remodeling, cell migration, and tissue repair by influencing cytoskeletal organization and signaling pathways. Unlike Nogo-A, which is known for inhibiting nerve regeneration, Nogo-B is more involved in maintaining vascular homeostasis and modulating inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurite outgrowth inhibitor; Nogo protein; Reticulon-4
Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; Kiaa0886; mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL; Rtn4
UniProt ID: (Mouse) Q99P72
Entrez Gene ID: (Mouse) 68585
angiogenesis
nervous system development
axonogenesis
axonal fasciculation
negative regulation of neuron projection development
cerebral cortex radial glia guided migration
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of dopamine secretion
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
negative regulation of axonogenesis
regulation of sensory perception of pain
regulation of nervous system development
cardiac epithelial to mesenchymal transition
negative regulation of neuron projection regeneration
endoplasmic reticulum tubular network organization
regulation of branching morphogenesis of a nerve
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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