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Invitrogen
Endophilin B1/B2 Monoclonal Antibody (807009)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61825
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
807009
Immunogen
E. coli-derived recombinant human Endophilin B1/Bif-1, Ala33-Asn189
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Endophilin B1 (SH3GLB1) and Endophilin B2 (SH3GLB2) are genes that encode proteins belonging to the endophilin family, which are involved in various cellular processes, particularly those related to membrane dynamics and vesicular trafficking. These proteins are characterized by their SH3 domains, which facilitate interactions with other proteins, and their BAR domains, which bind to and shape cellular membranes. Endophilin B1 and B2 play crucial roles in the regulation of endocytosis, autophagy, and mitochondrial dynamics. They are especially important in the maintenance of mitochondrial integrity and function, as well as in the formation of autophagosomes, which are essential for the degradation and recycling of cellular components. Dysregulation or mutations in these genes can lead to impaired autophagy and mitochondrial dysfunction, contributing to the pathogenesis of various diseases, including neurodegenerative disorders like Parkinson's and Alzheimer's disease, and certain cancers. Research into Endophilin B1 and B2 provides valuable insights into their roles in cellular homeostasis and offers potential therapeutic targets for conditions involving defective membrane trafficking and autophagy. Understanding their mechanisms and interactions is key to developing strategies to modulate their activity for therapeutic benefit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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