Search
Invitrogen
Viral MIP-I Monoclonal Antibody (84420)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA5-61893
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
84420
Immunogen
E. coli-derived recombinant human herpes virus-8 MIP-I, Ala25-Ala95
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
MIP-1, also known as Macrophage Inflammatory Protein-1, is a chemokine encoded by the CCL3 gene. This protein is a member of the CC chemokine family and plays a critical role in the immune response by recruiting and activating various types of leukocytes, including macrophages, T cells, and dendritic cells, to sites of infection or injury. MIP-1 is involved in the inflammatory response, promoting the release of other cytokines and chemokines that amplify the immune reaction. It binds to specific receptors on the surface of target cells, such as CCR1 and CCR5, to exert its effects. Elevated levels of MIP-1 have been associated with various inflammatory and autoimmune conditions, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Additionally, MIP-1 is implicated in the pathogenesis of certain cancers and HIV infection, where it can influence tumor progression and viral replication. Understanding the regulation and function of MIP-1 is crucial for developing targeted therapies aimed at modulating immune responses and treating diseases characterized by excessive inflammation or immune dysregulation. Research into MIP-1 also provides insights into the broader mechanisms of chemokine-mediated cell signaling and its potential therapeutic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support