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Invitrogen
20S Immunoproteasome Monoclonal Antibody (894505)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61924
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
894505
Immunogen
Human 20S Immunoproteasome purified from peripheral blood mononuclear cells
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The 20S immunoproteasome is a specialized form of the proteasome complex that plays a crucial role in the immune system by processing intracellular proteins into peptides for presentation on major histocompatibility complex (MHC) class I molecules. This process is essential for the recognition of infected or malignant cells by cytotoxic T lymphocytes. The immunoproteasome is composed of unique catalytic subunits, including LMP2 (PSMB9), LMP7 (PSMB8), and MECL-1 (PSMB10), which replace their constitutive counterparts in the standard proteasome. These subunits enhance the generation of peptides that are optimal for MHC class I binding. The formation of the immunoproteasome is induced by inflammatory cytokines such as interferon-gamma (IFN-gamma), which are released during immune responses to infections or tumors. Beyond its role in antigen presentation, the immunoproteasome also contributes to the regulation of cytokine production and the maintenance of protein homeostasis under stress conditions. Dysregulation or mutations in the components of the immunoproteasome have been implicated in various autoimmune diseases, such as lupus and rheumatoid arthritis, as well as in certain cancers. Understanding the function and regulation of the 20S immunoproteasome is important for developing therapeutic strategies aimed at modulating immune responses, enhancing cancer immunotherapy, and treating autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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