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Invitrogen

p40 (DeltaNp63) Recombinant Rabbit Monoclonal Antibody (RM392)

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Product Details

MA562093

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

RM392

Immunogen

A peptide corresponding to Human p40 (DeltaNp63).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Purification

Protein A

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3703091

Product Specific Information

This antibody reacts to human p40 (deltaNp63).

Target Information

p40, also known as DeltaNp63, is an isoform of the p63 gene, which is a member of the p53 family of transcription factors. p63 plays a crucial role in the development and maintenance of epithelial tissues, and DeltaNp63 specifically acts as a dominant-negative inhibitor of p53 and other p63 isoforms. This inhibition is vital for the regulation of cell proliferation, differentiation, and apoptosis in epithelial cells. DeltaNp63 is highly expressed in the basal layers of epithelial tissues, including the skin, where it contributes to the regenerative capacity of these tissues. Abnormal expression of DeltaNp63 has been implicated in various cancers, particularly those originating from epithelial cells, such as squamous cell carcinoma. Understanding the function and regulation of p40/DeltaNp63 is essential for developing targeted therapies for these malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; deltaNp63delta; fifth splice variant; related to p53 and p73; first splice variant; related to p53 and p73; fourth splice variant; related to p53 and p73; keratinocyte transcription factor KET; p53-like; second splice variant; related to p53 and p73; sixth splice variant; related to p53 and p73; third splice variant; related to p53 and p73; transformation-related protein 63; tumor protein p53-competing protein; unnamed protein product

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Gene Aliases: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L

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UniProt ID: (Human) Q9H3D4

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Entrez Gene ID: (Human) 8626

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding identical protein binding sequence-specific DNA binding WW domain binding MDM2/MDM4 family protein binding promoter-specific chromatin binding
Process(es)
regulation of transcription, DNA-templated apoptotic process cellular response to DNA damage stimulus spermatogenesis positive regulation of cell proliferation regulation of epidermal cell division negative regulation of intracellular estrogen receptor signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein tetramerization establishment of skin barrier positive regulation of cell cycle G1/S phase transition positive regulation of somatic stem cell population maintenance positive regulation of fibroblast apoptotic process negative regulation of cellular senescence positive regulation of apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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