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Invitrogen
H4K12me1 Recombinant Rabbit Monoclonal Antibody (RM458)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA562169
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM458
Immunogen
A monomethyl-peptide corresponding to monomethyl-Histone H4 (Lys12).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts to Histone H4 monomethylated at Lysine 12 (K12me1). No cross reactivity with non-modified Lysine 12, or other monomethylations in histone H4.
Predicted to react with all vertebrates.
Target Information
H4K12me1 refers to the monomethylation of the 12th lysine residue on histone H4, a key post-translational modification involved in the regulation of chromatin structure and gene expression. Histones are proteins that package and order DNA into structural units called nucleosomes, and their modification can influence the accessibility of the DNA to the transcriptional machinery. The monomethylation at H4K12 is associated with both gene activation and repression, depending on the context within the chromatin landscape. This specific histone mark has been implicated in various cellular processes, including DNA repair, replication, and transcriptional regulation. Abnormal patterns of H4K12me1 have been linked to several diseases, including cancer, where they can affect the expression of oncogenes and tumor suppressor genes. Studying H4K12me1 and its regulatory mechanisms provides insights into the epigenetic control of gene expression and offers potential avenues for therapeutic intervention in disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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